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Título: | Evaluation of onion as a functional ingredient in the prevention of metabolic impairments associated to diet-induced hypercholesterolaemia using a multiplatform approach based on LC-MS, CE-MS and GC-MS |
Autor: | González Peña, Diana CSIC; Dudzik, Danuta; Colina Coca, Clara CSIC; Ancos, Begoña de CSIC ORCID ; García, Antonia; Barbas, Coral; Sánchez-Moreno, Concepción CSIC ORCID | Palabras clave: | Nutraceuticals Onion metabolism Plasma fingerprinting Metabolomics Functional foods High-cholesterol diet |
Fecha de publicación: | 2015 | Editor: | Elsevier | Citación: | Journal of Functional Foods 19: 363- 375 (2015) | Resumen: | The preventive and modulating effects of onion in metabolites affected by a high-cholesterol diet and related to molecular pathway dysfunction were examined. Plasma obtained from 24 male Wistar rats after seven weeks of experimental feeding was analysed through a non-targeted multiplatform metabolomics approach based on LC-MS, CE-MS and GC-MS methods. A cross-comparison of the three metabolic profiles [I) control (C) group, II) high-cholesterol (HC) group and III) high-cholesterol enriched with onion (HCO) group] pointed out two sulphur metabolites, S-methyl-L-cysteine and S-methylcysteine sulphoxide, as markers of onion intake and evidenced the possibilities to regulate key metabolites. Thus, the methylation cycle, arginine and tryptophan pathways, the modulation of 3-methylhistidine, as well as the routes involved in the glycerophospholipids transformation have been highlighted. This study suggests that onion's biologically active compounds take a prominent role in ameliorating hypercholesterolaemia and related complications through the regulation of altered metabolic pathways. | URI: | http://hdl.handle.net/10261/133540 | DOI: | 10.1016/j.jff.2015.09.033 | Identificadores: | doi: 10.1016/j.jff.2015.09.033 issn: 1756-4646 |
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