English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/133423
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

DC-SIGN<sup>+</sup> Macrophages Control the Induction of Transplantation Tolerance

AutorConde, P.; Rastrojo, Alberto ; Aguado, Begoña ; Ochando, Jordi
Fecha de publicación16-jun-2015
EditorCell Press
CitaciónImmunity 42: 1143- 1158 (2015)
Resumen© 2015 Elsevier Inc. Tissue effector cells of the monocyte lineage can differentiate into different cell types with specific cell function depending on their environment. The phenotype, developmental requirements, and functional mechanisms of immune protective macrophages that mediate the induction of transplantation tolerance remain elusive. Here, we demonstrate that costimulatory blockade favored accumulation of DC-SIGN-expressing macrophages that inhibited CD8<sup>+</sup> Tcell immunity and promoted CD4<sup>+</sup>Foxp3<sup>+</sup> Treg cell expansion in numbers. Mechanistically, that simultaneous DC-SIGN engagement by fucosylated ligands and TLR4 signaling was required for production of immunoregulatory IL-10 associated with prolonged allograft survival. Deletion of DC-SIGN-expressing macrophages invivo, interfering with their CSF1-dependent development, or preventing the DC-SIGN signaling pathway abrogated tolerance. Together, the results provide new insights into the tolerogenic effects of costimulatory blockade and identify DC-SIGN<sup>+</sup> suppressive macrophages as crucial mediators of immunological tolerance with the concomitant therapeutic implications in the clinic.
URIhttp://hdl.handle.net/10261/133423
DOI10.1016/j.immuni.2015.05.009
Identificadoresdoi: 10.1016/j.immuni.2015.05.009
issn: 1097-4180
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Aguado B DC SIGN+.pdf5,37 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.