English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/133049
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Expression of Serotonin2C Receptors in Pyramidal and GABAergic Neurons of Rat Prefrontal Cortex. A Comparison with Striatum

AutorSantana, Noemí ; Artigas, Francesc
Palabras clave5-HT2C receptors
Atypical antipsychotic drugs
GABA interneurons
Prefrontal cortex
Pyramidal neurons
Fecha de publicación1-jun-2016
EditorOxford University Press
CitaciónCerebral Cortex 1-15: 2016
ResumenThe prefrontal cortex (PFC) is enriched in several serotonin receptors, including 5-HT1A-R, 5- HT2A-R and 5-HT3-R. These receptors modulate PFC activity due to their expression in large neuronal populations (5-HT1A-R, 5-HT2A-R) or in selected GABAergic populations (5-HT3-R). They are also relevant for antidepressant and antipsychotic drug action. Less is known about the localization of 5-HT2C-R, for which atypical antipsychotics show high affinity. Here we report on the cellular distribution of 5-HT2C-R in rat PFC and striatum, using double in situ hybridization histochemistry. In PFC, 5-HT2C-R are expressed in pyramidal (VGLUT1-positive) and GABAergic (GAD-positive) neurons, including parvalbumin-positive neurons. There is a marked dorsoventral gradient in the proportion of VGLUT1-positive cells expressing 5-HT2C-R, (9% in cingulate cortex, 61% in tenia tecta and 66% in piriform cortex), less marked for GABAergic neurons (13-27%). There is also a laminar gradient, with more cells expressing 5-HT2C-R in deep (V-VI) than in intermediate (II-III) layers. In common with 5-HT3-R, layer I GABAergic cells express 5-HT2C-R. The proportion of 5-HT2C-R-expressing striatal neurons was 23% (dorsolateral caudate-putamen), 37% (ventromedial caudate-putamen), 53% (nucleus accumbens-core) and 49% (nucleus accumbens-shell). These results help to better understand the serotonergic modulation of PFC-based networks, including basal ganglia circuits, and atypical antipsychotic drug action.
Versión del editorhttp://dx.doi.org/10.1093/cercor/bhw148
URIhttp://hdl.handle.net/10261/133049
DOI10.1093/cercor/bhw148
Aparece en las colecciones: (IIBB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
2016_Santana_Cereb_Cortex_Postprint.pdf9,19 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.