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dc.contributor.authorSoler, Maríaes_ES
dc.contributor.authorEstévez, M. Carmenes_ES
dc.contributor.authorVillar-Vázquez, Roies_ES
dc.contributor.authorCasal, J. Ignacioes_ES
dc.contributor.authorLechuga, Laura M.es_ES
dc.date.accessioned2016-06-03T11:15:55Z-
dc.date.available2016-06-03T11:15:55Z-
dc.date.issued2016-08-03-
dc.identifier.citationAnalytica Chimica 930: 31–38 (2016)es_ES
dc.identifier.issn0003-2670-
dc.identifier.urihttp://hdl.handle.net/10261/132971-
dc.description57 p.-4 fig.-2 tab.es_ES
dc.description.abstractColorectal cancer is treatable and curable when detected at early stages. However there is a lack of less invasive and more specific screening and diagnosis methods which would facilitate its prompt identification. Blood circulating autoantibodies which are immediately produced by the immune system at tumor appearance have become valuable biomarkers for preclinical diagnosis of cancer. In this work, we present the rapid and label-free detection of colorectal cancer autoantibodies directly in blood serum or plasma using a recently developed nanoplasmonic biosensor. Our nanoplasmonic device offers sensitive and real-time quantification of autoantibodies with excellent selectivity and reproducibility, achieving limits of detection around 1 nM (150–160 ng mL−1). A preliminary evaluation of clinical samples of colorectal cancer patients has shown good correlation with ELISA. These results demonstrate the reliability of the nanobiosensor strategy and pave the way towards the achievement of a sensitive diagnostic tool for early detection of colorectal cancer.es_ES
dc.description.sponsorshipM. Soler acknowledges financial support from “Programa de Formación de Personal Investigador (FPI)” from the Spanish Ministry of Economy and Competitiveness (MINECO). R. Villar-Vazquez was a recipient of a FPU fellowship from the Spanish Ministry of Education and Culture. We acknowledge the financial support from COLONTEST project (RETOS-COLABORACIÓN Subprogram, RTC-2014-1518-1). The NanoB2A is a consolidated research group (Grup de Recerca) of the Generalitat de Catalunya and has support from the Departament d’Universitats, Recerca i Societat de la Informació de la Generalitat de Catalunya (2014 SGR 624). ICN2 is the recipient of Grant SEV-2013-0295 from the “Severo Ochoa Centers of Excellence” Program of Spanish MINECO. In addition, JI Casal was supported by the grant BIO2012-31023 from the MINECO.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relationMINECO/ICTI2013-2016/SEV-2013-0295-
dc.relationMINECO/ICTI2013-2016/RTC-2014-1518-1-
dc.relation.isversionofPostprintes_ES
dc.rightsopenAccessen_EN
dc.subjectNanoplasmonic biosensor;es_ES
dc.subjectPlasmaes_ES
dc.subjectSerumes_ES
dc.subjectColorectal canceres_ES
dc.subjectAutoantibodieses_ES
dc.subjectClinical diagnosises_ES
dc.titleLabel-free nanoplasmonic sensing of tumor-associate autoantibodies for early diagnosis of colorectal canceres_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.aca.2016.04.059-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/ 10.1016/j.aca.2016.04.059es_ES
dc.identifier.e-issn1873-4324-
dc.embargo.terms2017-08-03es_ES
dc.rights.licensehttp://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.contributor.funderMinisterio de Economía y Competitividad (España)es_ES
dc.contributor.funderMinisterio de Educación y Cultura (España)es_ES
dc.contributor.funderGeneralitat de Catalunyaes_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003329es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002809es_ES
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