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dc.contributor.authorDíaz-Marrero, Ana R.en_US
dc.contributor.authorDorta, Enriqueen_US
dc.contributor.authorCueto, Mercedesen_US
dc.contributor.authorRovirosa, Juanaen_US
dc.contributor.authorSan Martín, Aurelioen_US
dc.contributor.authorLoyola, Luis Albertoen_US
dc.contributor.authorDarias, José-
dc.date.accessioned2009-05-28T07:17:27Z-
dc.date.available2009-05-28T07:17:27Z-
dc.date.issued2003-08-15en_US
dc.identifier.citationArkivoc: Online Journal of Organic Chemistry 2003(10): 107-117 (2003)en_US
dc.identifier.issn1424-6376-
dc.identifier.urihttp://hdl.handle.net/10261/13276-
dc.description11 pages, 7 figures, 2 tables.-
dc.description.abstractTwo new sterols, 1-2, unusually hydroxylated at C-21 have been isolated from the marine pulmonate Trimusculus peruvianus. Compound 2 possesses a Δ7-3α,5α,6β-triol nucleus unprecedented in marine organisms. The structure and stereochemistries were determined on the basis of spectral studies, particularly NMR and MS spectroscopic data. 1 and 2 are the entire sterol content of the mollusk and both exhibit moderate in vitro cytotoxic activity against human colon carcinoma cell lines.-
dc.description.sponsorshipThis work was supported by the Ministerio de Ciencia y Tecnología (MCYT), project ref: PPQ2002-02494, DGUI of the Canary Islands Government PI2002/044, DID project CSMAR 02/6-2 of the Universidad de Chile, Cooperation Program between CSIC (Spain)-CONICYT (Chile), and DI of the Universidad de Antofagasta. We are grateful to BIOMAR, S.A., for performing the bioassays. A. R. D.-M. acknowledges an I3P grant from the CSIC and E. D. an FPI grant from the MCYT.-
dc.format.extent2373 bytes-
dc.format.extent74068 bytes-
dc.format.mimetypetext/plain-
dc.format.mimetypeapplication/pdf-
dc.language.isoengen_US
dc.publisherArkat USA-
dc.rightsopenAccessen_US
dc.subjectMarine mollusk-
dc.subjectTrimusculus peruvianus-
dc.subjectΔ5- and Δ7-polyhydroxylated steroids-
dc.subjectCytotoxic activity-
dc.titleNew polyhydroxylated steroids from the marine pulmonate Trimusculus peruvianusen_US
dc.typeartículoen_US
dc.relation.publisherversionhttp://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/2003/10/-
dc.identifier.e-issn1424-6369-
dc.contributor.funderMinisterio de Ciencia y Tecnología (España)-
dc.contributor.funderGobierno de Canarias-
dc.contributor.funderUniversidad de Chile-
dc.contributor.funderConsejo Superior de Investigaciones Científicas (España)-
dc.contributor.funderComisión Nacional de Investigación Científica y Tecnológica (Chile)-
dc.contributor.funderUniversidad de Antofagasta-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100006280es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100005853es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003339es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100002848es_ES
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