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New polyhydroxylated steroids from the marine pulmonate Trimusculus peruvianus

AuthorsDíaz-Marrero, Ana R. ; Dorta, Enrique ; Cueto, Mercedes ; Rovirosa, Juana; San Martín, Aurelio; Loyola, Luis Alberto; Darias, José
KeywordsMarine mollusk
Trimusculus peruvianus
Δ5- and Δ7-polyhydroxylated steroids
Cytotoxic activity
Issue Date15-Aug-2003
PublisherArkat USA
CitationArkivoc: Online Journal of Organic Chemistry 2003(10): 107-117 (2003)
AbstractTwo new sterols, 1-2, unusually hydroxylated at C-21 have been isolated from the marine pulmonate Trimusculus peruvianus. Compound 2 possesses a Δ7-3α,5α,6β-triol nucleus unprecedented in marine organisms. The structure and stereochemistries were determined on the basis of spectral studies, particularly NMR and MS spectroscopic data. 1 and 2 are the entire sterol content of the mollusk and both exhibit moderate in vitro cytotoxic activity against human colon carcinoma cell lines.
Description11 pages, 7 figures, 2 tables.
Publisher version (URL)http://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/2003/10/
Appears in Collections:(IPNA) Artículos
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