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dc.contributor.authorMitchell, Emmaes_ES
dc.contributor.authorKlein, Shifra L.es_ES
dc.contributor.authorArgyropoulos, Kimon V.es_ES
dc.contributor.authorSharma, Alies_ES
dc.contributor.authorChan, Robin B.es_ES
dc.contributor.authorGal Toth, Judites_ES
dc.contributor.authorBarboza, Luendreoes_ES
dc.contributor.authorBavley, Charlottees_ES
dc.contributor.authorBortolozzi, Analíaes_ES
dc.contributor.authorChen, Qiuyinges_ES
dc.contributor.authorLiu, Bingfanges_ES
dc.contributor.authorIngenito, Joannees_ES
dc.contributor.authorMark, Williees_ES
dc.contributor.authorDudakov, Jarrodes_ES
dc.contributor.authorGross, Stevenes_ES
dc.contributor.authorDi Paolo, Gilbertoes_ES
dc.contributor.authorArtigas, Francesces_ES
dc.contributor.authorvan den Brink, Marceles_ES
dc.contributor.authorToth, Mikloses_ES
dc.date.accessioned2016-05-30T10:59:23Z-
dc.date.available2016-05-30T10:59:23Z-
dc.date.issued2016-05-13-
dc.identifier.citationNature Communications 7 (11492): 2016es_ES
dc.identifier.urihttp://hdl.handle.net/10261/132753-
dc.description.abstractParental behavioural traits can be transmitted by non-genetic mechanisms to the offspring. Although trait transmission via sperm has been extensively researched, epidemiological studies indicate the exclusive/prominent maternal transmission of many non-genetic traits. Since maternal conditions impact the offspring during gametogenesis and through fetal/early-postnatal life, the resultant phenotype is likely the aggregate of consecutive germline and somatic effects; a concept that has not been previously studied. Here, we dissected a complex maternally transmitted phenotype, reminiscent of comorbid generalized anxiety/depression, to elementary behaviours/domains and their transmission mechanisms in mice. We show that four anxiety/stress-reactive traits are transmitted via independent iterative-somatic and gametic epigenetic mechanisms across multiple generations. Somatic/gametic transmission alters DNA methylation at enhancers within synaptic genes whose functions can be linked to the behavioural traits. Traits have generation-dependent penetrance and sex specificity resulting in pleiotropy. A transmission-pathway-based concept can refine current inheritance models of psychiatric diseases and facilitate the development of better animal models and new therapeutic approaches.es_ES
dc.description.sponsorshipWe are grateful for grant support R01-MH103102 and R21-MH103715 from the NIH to M.T., PO1-HD067244 and R37-HL87062 to S.S.G., 2R01-NS056049 to G.D.P., R01-HL069929, R01-AI080455 and R01-AI101406 to M.R.M. Also supported by the Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) and grants SAF2015-68346-P to F.A. and PI13/01390 to A.B., co-financed by the European Regional Development Fund. E.M. was supported in part by NIH T32-GM073546.es_ES
dc.language.isoenges_ES
dc.publisherNature Publishing Groupes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.subjectBiological scienceses_ES
dc.subjectGeneticses_ES
dc.subjectNeuroscienceses_ES
dc.titleBehavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanismses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1038/ncomms11492-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1038/ncomms11492es_ES
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderNational Institutes of Health (US)es_ES
dc.contributor.funderInstituto de Salud Carlos IIIes_ES
dc.contributor.funderCentro de Investigación Biomédica en Red Salud Mental (España)es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.relation.csices_ES
oprm.item.hasRevisionno ko 0 false*
dc.identifier.funderhttp://dx.doi.org/10.13039/100000002es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100004587es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100006751es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.pmid27173585-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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