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http://hdl.handle.net/10261/132753
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dc.contributor.author | Mitchell, Emma | es_ES |
dc.contributor.author | Klein, Shifra L. | es_ES |
dc.contributor.author | Argyropoulos, Kimon V. | es_ES |
dc.contributor.author | Sharma, Ali | es_ES |
dc.contributor.author | Chan, Robin B. | es_ES |
dc.contributor.author | Gal Toth, Judit | es_ES |
dc.contributor.author | Barboza, Luendreo | es_ES |
dc.contributor.author | Bavley, Charlotte | es_ES |
dc.contributor.author | Bortolozzi, Analía | es_ES |
dc.contributor.author | Chen, Qiuying | es_ES |
dc.contributor.author | Liu, Bingfang | es_ES |
dc.contributor.author | Ingenito, Joanne | es_ES |
dc.contributor.author | Mark, Willie | es_ES |
dc.contributor.author | Dudakov, Jarrod | es_ES |
dc.contributor.author | Gross, Steven | es_ES |
dc.contributor.author | Di Paolo, Gilberto | es_ES |
dc.contributor.author | Artigas, Francesc | es_ES |
dc.contributor.author | van den Brink, Marcel | es_ES |
dc.contributor.author | Toth, Miklos | es_ES |
dc.date.accessioned | 2016-05-30T10:59:23Z | - |
dc.date.available | 2016-05-30T10:59:23Z | - |
dc.date.issued | 2016-05-13 | - |
dc.identifier.citation | Nature Communications 7 (11492): 2016 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/132753 | - |
dc.description.abstract | Parental behavioural traits can be transmitted by non-genetic mechanisms to the offspring. Although trait transmission via sperm has been extensively researched, epidemiological studies indicate the exclusive/prominent maternal transmission of many non-genetic traits. Since maternal conditions impact the offspring during gametogenesis and through fetal/early-postnatal life, the resultant phenotype is likely the aggregate of consecutive germline and somatic effects; a concept that has not been previously studied. Here, we dissected a complex maternally transmitted phenotype, reminiscent of comorbid generalized anxiety/depression, to elementary behaviours/domains and their transmission mechanisms in mice. We show that four anxiety/stress-reactive traits are transmitted via independent iterative-somatic and gametic epigenetic mechanisms across multiple generations. Somatic/gametic transmission alters DNA methylation at enhancers within synaptic genes whose functions can be linked to the behavioural traits. Traits have generation-dependent penetrance and sex specificity resulting in pleiotropy. A transmission-pathway-based concept can refine current inheritance models of psychiatric diseases and facilitate the development of better animal models and new therapeutic approaches. | es_ES |
dc.description.sponsorship | We are grateful for grant support R01-MH103102 and R21-MH103715 from the NIH to M.T., PO1-HD067244 and R37-HL87062 to S.S.G., 2R01-NS056049 to G.D.P., R01-HL069929, R01-AI080455 and R01-AI101406 to M.R.M. Also supported by the Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) and grants SAF2015-68346-P to F.A. and PI13/01390 to A.B., co-financed by the European Regional Development Fund. E.M. was supported in part by NIH T32-GM073546. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Nature Publishing Group | es_ES |
dc.relation.isversionof | Publisher's version | es_ES |
dc.rights | openAccess | es_ES |
dc.subject | Biological sciences | es_ES |
dc.subject | Genetics | es_ES |
dc.subject | Neurosciences | es_ES |
dc.title | Behavioural traits propagate across generations via segregated iterative-somatic and gametic epigenetic mechanisms | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1038/ncomms11492 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1038/ncomms11492 | es_ES |
dc.rights.license | http://creativecommons.org/licenses/by/4.0/ | es_ES |
dc.contributor.funder | National Institutes of Health (US) | es_ES |
dc.contributor.funder | Instituto de Salud Carlos III | es_ES |
dc.contributor.funder | Centro de Investigación Biomédica en Red Salud Mental (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.relation.csic | Sí | es_ES |
oprm.item.hasRevision | no ko 0 false | * |
dc.identifier.funder | http://dx.doi.org/10.13039/100000002 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004587 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100006751 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.pmid | 27173585 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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Artigas_ncomms11492_2016.pdf | 1,22 MB | Adobe PDF | Visualizar/Abrir |
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