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Title

Labdane diterpenes with a new oxidation pattern from the marine pulmonate Trimusculus peruvianus

AuthorsDíaz-Marrero, Ana R. ; Dorta, Enrique ; Cueto, Mercedes ; Rovirosa, Juana; San Martín, Aurelio; Loyola, Luis Alberto; Darias, José
KeywordsLabdane diterpenes
Pulmonate
Carcinoma
Issue Date4-Jun-2003
PublisherElsevier
CitationTetrahedron 59(26): 4805-4809 (2003)
AbstractFour new labdane diterpenes, 1-4, with an unusual oxidation pattern have been isolated from the marine pulmonate Trimusculus peruvianus. The structure and stereochemistry of these compounds were determined by spectroscopic data and chemical transformations. The absolute stereochemistry of 4 was assigned by application of the modified Mosher method. These compounds exhibit in vitro moderate cytotoxic activity against human colon carcinoma cell lines.
Description5 pages, 2 figures, 1 table.-- Printed version published Jun 23, 2003.
Publisher version (URL)http://dx.doi.org/10.1016/S0040-4020(03)00731-2
URIhttp://hdl.handle.net/10261/13271
DOI10.1016/S0040-4020(03)00731-2
ISSN0040-4020
Appears in Collections:(IPNA) Artículos
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