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Título

From conjugated tertiary skipped diynes to chain-functionalized tetrasubstituted pyrroles

AutorTejedor, David ; López-Tosco, Sara ; González-Platas, Javier; García-Tellado, Fernando
Fecha de publicación12-ene-2009
EditorJohn Wiley & Sons
CitaciónChemistry - A European Journal 15: 838-842 (2009)
ResumenA novel and metal-free method for the synthesis of chain-functionalized tetrasubstituted pyrroles from easily accessible tertiary skipped diynes, was reported. The method involved modular synthesis of chain functionalized tetrasubstituted pyrroles from easily available alkyl porpiolates, acid chlorides, and primary amine. The method used a primary amine for the nitrogen source and utilized the reactivity profile of tertiary 1,4-diyne scaffolds. The synthetic manifold in the method operated in the absence of metals and accelerated by the nucleophilic addition of a primary amine on the alkynoate function. Anti-Michael ring-closing hydroamination and a [3,3]-sigmatropic rearrangement helped to complete the process of producing pyrrole. It was observed during the process that the enamine formation is more faster than the enamine cyclization.
Versión del editorhttp://dx.doi.org/10.1002/chem.200802262
URIhttp://hdl.handle.net/10261/132612
DOI10.1002/chem.200802262
Identificadoresissn: 0947-6539
e-issn: 1521-3765
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