English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/132407
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

New applications for known drugs: Human glycogen synthase kinase 3 inhibitors as modulators of Aspergillus fumigatus growth

AutorSebastián, Víctor; Manoli, Maria-Tsampika; Pérez, Daniel I.; Gil, Carmen ; Mellado, Emilia; Martínez, Ana ; Espeso, Eduardo A. ; Campillo, Nuria E.
Palabras claveAspergillus nidulans
Aspergillus fumigatus
Docking
Fpocket
GSK-3 inhibitors
Fecha de publicación30-jun-2016
EditorElsevier
CitaciónEuropean Journal of Medicinal Chemistry 116: 281–289 (2016)
ResumenInvasive aspergillosis (IA) is one of the most severe forms of fungi infection. IA disease is mainly due to Aspergillus fumigatus, an air-borne opportunistic pathogen. Mortality rate caused by IA is still very high (50–95%), because of difficulty in early diagnostics and reduced antifungal treatment options, thus new and efficient drugs are necessary. The aim of this work is, using Aspergillus nidulans as non-pathogen model, to develop efficient drugs to treat IA. The recent discovered role of glycogen synthase kinase-3 homologue, GskA, in A. fumigatus human infection and our previous experience on human GSK-3 inhibitors focus our attention on this kinase as a target for the development of antifungal drugs. With the aim to identify effective inhibitors of colonial growth of A. fumigatus we use A. nidulans as an accurate model for in vivo and in silico studies. Several well-known human GSK-3β inhibitors were tested for inhibition of A. nidulans colony growth. Computational tools as docking studies and binding site prediction was used to explain the different biological profile of the tested inhibitors. Three of the five tested hGSK3β inhibitors are able to reduce completely the colonial growth by covalent bind to the enzyme. Therefore these compounds may be useful in different applications to eradicate IA.
Descripción27 p.-8 fig.-2 tab.
Versión del editorhttp://dx.doi.org/ 10.1016/j.ejmech.2016.03.035
URIhttp://hdl.handle.net/10261/132407
DOI10.1016/j.ejmech.2016.03.035
ISSN0223-5234
E-ISSN1768-3254
Aparece en las colecciones: (CIB) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
EJMECH_N. Campillo.pdfPostprint2,55 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.