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Título

Mulinane-type diterpenoids from Azorella compacta display antiplasmodial activity

AutorLoyola, Luis Alberto; Bórquez, Jorge; Morales, Glauco; San Martín, Aurelio; Darias, José ; Flores, Ninoska; Giménez, Alberto P.
Palabras claveAzorella compacta
Umbelliferae
Diterpenoids
Plasmodium berghei
Fecha de publicaciónjul-2004
EditorElsevier
CitaciónPhytochemistry 65(13): 1931-1935 (2004)
ResumenTwo mulinane-type diterpenoids were isolated from Azorella compacta; namely 20-hydroxymulin-11,13-dienyl acetate and 13,14-dihydroxymulin-11-en-20-oic acid. The structures were elucidated by analysis of their spectroscopic data. These compounds, as well as three previously isolated diterpenes, were evaluated as potential in vivo growth inhibitors of Plasmodium berghei NK 65 on infected mice at an intraperitoneal dose of 10 mg/kg/day. Sixty percent and forty-two percent growth inhibition were obtained with 17-acetoxymulin-11,13-dien-20-oic acid and 13, 14-dihydroxymulin-11-en-20-oic acid, respectively.
Descripción5 pages, 2 tables.-- PMID: 15280000 [PubMed].
Versión del editorhttp://dx.doi.org/10.1016/j.phytochem.2004.06.011
URIhttp://hdl.handle.net/10261/13235
DOI10.1016/j.phytochem.2004.06.011
ISSN0031-9422
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