Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/13178
COMPARTIR / EXPORTAR:
![]() ![]() |
|
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
![Invitar a revisión por pares abierta](/image/oprm_dc_invitacion_ES.jpg)
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Arsequell, Gemma | - |
dc.contributor.author | Salvatella, Mariona | - |
dc.contributor.author | Valencia Parera, Gregorio | - |
dc.contributor.author | Fernández-Mayoralas, Alfonso | - |
dc.contributor.author | Fontanella, Marco | - |
dc.contributor.author | Venturi, Chiara | - |
dc.contributor.author | Jiménez-Barbero, Jesús | - |
dc.contributor.author | Marrón Fernández de Velasco, E. | - |
dc.contributor.author | Rodríguez, Raquel E. | - |
dc.date.accessioned | 2009-05-23T19:08:52Z | - |
dc.date.available | 2009-05-23T19:08:52Z | - |
dc.date.issued | 2009-04-07 | - |
dc.identifier.citation | Journal of Medicinal Chemistry 52(9): 2656-2666 (2009) | en_US |
dc.identifier.issn | 0022-2623 | - |
dc.identifier.uri | http://hdl.handle.net/10261/13178 | - |
dc.description | 11 pages.-- PMID: 19351163 [PubMed].-- Printed version published May 14, 2009. | en_US |
dc.description | Supporting information (10 pages) available at: http://pubs.acs.org/doi/suppl/10.1021/jm8011245/suppl_file/jm8011245_si_001.pdf | - |
dc.description.abstract | A synthetic mannoside derivative, namely, 6-morphinyl-α-d-mannopyranoside, shows a naloxone-reversible antinociception that is 100-fold more potent and twice as long lasting compared to morphine when administered intraperitoneally to rats in paw pressure and tail flick tests. The compound does not produce tolerance and binds to rat μ opioid receptors with twice the affinity of morphine. NMR studies suggest that differences of activity between the derivative and its parent compound M6G might be related to their differing molecular dynamic behavior. | en_US |
dc.format.extent | 48270 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | American Chemical Society | en_US |
dc.rights | closedAccess | en_US |
dc.title | Synthesis, conformation, and biological characterization of a sugar derivative of morphine that is a potent, long-lasting, and nontolerant antinociceptive | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1021/jm8011245 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1021/jm8011245 | en_US |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (IQAC) Artículos (IQOG) Artículos (CIB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Antinociceptive_Press_release.pdf | CSIC Press release (Spanish lang.) | 47,14 kB | Adobe PDF | ![]() Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
14
checked on 25-mar-2024
WEB OF SCIENCETM
Citations
14
checked on 15-feb-2024
Page view(s)
446
checked on 23-abr-2024
Download(s)
308
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.