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| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Arsequell, Gemma | - |
| dc.contributor.author | Salvatella, Mariona | - |
| dc.contributor.author | Valencia Parera, Gregorio | - |
| dc.contributor.author | Fernández-Mayoralas, Alfonso | - |
| dc.contributor.author | Fontanella, Marco | - |
| dc.contributor.author | Venturi, Chiara | - |
| dc.contributor.author | Jiménez-Barbero, Jesús | - |
| dc.contributor.author | Marrón Fernández de Velasco, E. | - |
| dc.contributor.author | Rodríguez, Raquel E. | - |
| dc.date.accessioned | 2009-05-23T19:08:52Z | - |
| dc.date.available | 2009-05-23T19:08:52Z | - |
| dc.date.issued | 2009-04-07 | - |
| dc.identifier.citation | Journal of Medicinal Chemistry 52(9): 2656-2666 (2009) | en_US |
| dc.identifier.issn | 0022-2623 | - |
| dc.identifier.uri | http://hdl.handle.net/10261/13178 | - |
| dc.description | 11 pages.-- PMID: 19351163 [PubMed].-- Printed version published May 14, 2009. | en_US |
| dc.description | Supporting information (10 pages) available at: http://pubs.acs.org/doi/suppl/10.1021/jm8011245/suppl_file/jm8011245_si_001.pdf | - |
| dc.description.abstract | A synthetic mannoside derivative, namely, 6-morphinyl-α-d-mannopyranoside, shows a naloxone-reversible antinociception that is 100-fold more potent and twice as long lasting compared to morphine when administered intraperitoneally to rats in paw pressure and tail flick tests. The compound does not produce tolerance and binds to rat μ opioid receptors with twice the affinity of morphine. NMR studies suggest that differences of activity between the derivative and its parent compound M6G might be related to their differing molecular dynamic behavior. | en_US |
| dc.format.extent | 48270 bytes | - |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | en_US |
| dc.publisher | American Chemical Society | en_US |
| dc.rights | closedAccess | en_US |
| dc.title | Synthesis, conformation, and biological characterization of a sugar derivative of morphine that is a potent, long-lasting, and nontolerant antinociceptive | en_US |
| dc.type | artículo | en_US |
| dc.identifier.doi | 10.1021/jm8011245 | - |
| dc.description.peerreviewed | Peer reviewed | en_US |
| dc.relation.publisherversion | http://dx.doi.org/10.1021/jm8011245 | en_US |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
| item.openairetype | artículo | - |
| item.grantfulltext | open | - |
| item.cerifentitytype | Publications | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| item.fulltext | With Fulltext | - |
| item.languageiso639-1 | en | - |
| Aparece en las colecciones: | (IQAC) Artículos (IQOG) Artículos (CIB) Artículos | |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| Antinociceptive_Press_release.pdf | CSIC Press release (Spanish lang.) | 47,14 kB | Adobe PDF |  Visualizar/Abrir |
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