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Título

Aromatic esters of bicyclic amines as antimicrobials against Streptococcus pneumoniae

Otros títulosAromatic esters of bicyclic amines: a new generation of antimicrobials against Streptococcus pneumoniae
AutorRetamosa Hernández, María Gracia; Díez-Martínez, Roberto ; Maestro, Beatriz; García-Fernández, Esther; de Waal, Bas; Meijer, E. W.; García, Pedro ; Sanz, Jesús M.
Palabras clavePneumococcus
Antibiotic resistance
Drug design
Choline-binding proteins
Dendrimers
Fecha de publicación17-sep-2015
EditorWiley-VCH
CitaciónAngewandte Chemie (2015)
ResumenA double approach was followed in the search of novel inhibitors of the surface choline-binding proteins (CBPs) of Streptococcus pneumoniae (pneumococcus) with antimicrobial properties. First, a library of 49 rationally-designed esters of alkyl amines was screened for their specific binding to CBPs. The best binders, being esters of bicyclic amines (EBAs), were then tested for their in vitro effect on pneumococcal growth and morphology. Second, the efficiency of EBA-induced CBP inhibition was enhanced about 45 000-fold by multivalency effects upon synthesizing a poly(propylene imine) dendrimer containing eight copies of an atropine derivative. Both approaches led to compounds that arrest bacterial growth, dramatically decrease cell viability, and exhibit a protection effect in animal disease models, demonstrating that the pneumococcal CBPs are adequate targets for the discovery of novel antimicrobials that overcome the currently increasing antimicrobial resistance issues.
Descripción1 schem.-2 tab.-3 fig.
Versión del editorhttp://dx.doi.org/ 10.1002/ange.201505700
URIhttp://hdl.handle.net/10261/131014
DOI10.1002/ange.201505700
ISSN1433-7851
E-ISSN1433-7851
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