English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/131009
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Lipidomics to analyze the influence of diets with different EPA:DHA ratios in the progression of Metabolic Syndrome using SHROB rats as a model

AuthorsDasilva, Gabriel ; Pazos, Manuel ; García-Egido, Manuel; Pérez-Jiménez, Jara ; Torres, Josep Lluís ; Giralt, Montse; Nogués, M. R.; Medina, Isabel
KeywordsLipid mediators
Metabolic Syndrome
Oxidative stress
Issue Date2016
CitationFood Chemistry 205: 196–203 (2016)
AbstractThe role of specific proportions of ω-3 EPA and DHA, in the modulation of inflammation and oxidative stress markers associated to the progression of Metabolic Syndrome was investigated. Potential inflammatory eicosanoids and docosanoids were discussed together to biomarkers of CVD, obesity, inflammation and oxidative stress in an animal model of metabolic disorders. Results evidenced a noteworthy health effect of 1:1 and 2:1 EPA:DHA proportions over 1:2 EPA:DHA based diets through a down-regulation in the production of strong pro-inflammatory ω-6 eicosanoids, a decrement of biomarkers of oxidative stress, and a modulation of fatty acid desaturase activities and plasma and membrane PUFAs towards greater anti-inflammatory profiles. Outcomes contribute to the general knowledge on the health benefits of marine lipids and their role on the progress of MetS, inflammation and oxidative stress. Results shed light on controversial protective mechanisms of EPA and DHA to better design dietary interventions aimed at reducing MetS
Description8 páginas, 4 tablas
Publisher version (URL)http://dx.doi.org/10.1016/j.foodchem.2016.03.020
Appears in Collections:(IIM) Artículos
Files in This Item:
File Description SizeFormat 
Lipidomics_analyze_influence.pdf518,74 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.