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http://hdl.handle.net/10261/130949
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dc.contributor.author | Pascual-Ahuir, Amparo | - |
dc.contributor.author | Vanacloig-Pedros, Elena | - |
dc.contributor.author | Proft, Markus | - |
dc.date.accessioned | 2016-04-11T10:58:09Z | - |
dc.date.available | 2016-04-11T10:58:09Z | - |
dc.date.issued | 2014-05-22 | - |
dc.identifier | issn: 2072-6643 | - |
dc.identifier.citation | Nutrients 6: 2077-2087 (2014) | - |
dc.identifier.uri | http://hdl.handle.net/10261/130949 | - |
dc.description.abstract | Mycotoxins are important food contaminants and a serious threat for human nutrition. However, in many cases the mechanisms of toxicity for this diverse group of metabolites are poorly understood. Here we apply live cell gene expression reporters in yeast as a quantitative model to unravel the cellular defense mechanisms in response to the mycotoxin citrinin. We find that citrinin triggers a fast and dose dependent activation of stress responsive promoters such as GRE2 or SOD2. More specifically, oxidative stress responsive pathways via the transcription factors Yap1 and Skn7 are critically implied in the response to citrinin. Additionally, genes in various multidrug resistance transport systems are functionally involved in the resistance to citrinin. Our study identifies the antioxidant defense as a major physiological response in the case of citrinin. In general, our results show that the use of live cell gene expression reporters in yeast are a powerful tool to identify toxicity targets and detoxification mechanisms of a broad range of food contaminants relevant for human nutrition. © 2014 by the authors; licensee MDPI, Basel, Switzerland. | - |
dc.description.sponsorship | This work was supported by Ministerio de Economía y Competitividad grant BFU2011-23326. We thank the Fond for Open Access Publication from Consejo Superior de Investigaciones Científicas for supporting publication costs of this article. | - |
dc.description.sponsorship | We acknowledge support by the CSIC Open Access Publication Initiative through its Unit of Information Resources for Research (URICI). | - |
dc.publisher | Multidisciplinary Digital Publishing Institute | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Citrinin | - |
dc.subject | mycotoxins | - |
dc.subject | yeast | - |
dc.subject | oxidative stress | - |
dc.title | Toxicity mechanisms of the food contaminant citrinin: Application of a quantitative yeast model | - |
dc.type | artículo | - |
dc.identifier.doi | 10.3390/nu6052077 | - |
dc.relation.publisherversion | http://dx.doi.org/10.3390/nu6052077 | - |
dc.date.updated | 2016-04-11T10:58:09Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by/3.0/ | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.pmid | 24858409 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.fulltext | With Fulltext | - |
item.cerifentitytype | Publications | - |
Aparece en las colecciones: | (IBMCP) Artículos |
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Toxicity_mechanism_Pascual-Ahuir.pdf | 1,31 MB | Adobe PDF | Visualizar/Abrir |
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