English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/130613
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

DMSO affects Aβ<inf>1-40</inf>'s conformation and interactions with aggregation inhibitors as revealed by NMR

AuthorsLaurents, D.V. ; Pantoja-Uceda, D.; López, L. C.; Carrodeguas, José A.; Mompeán, M.; Jiménez, M. Angeles ; Sancho, Javier
Issue Date2015
CitationRSC Advances 5: 69761- 69764 (2015)
Abstract© The Royal Society of Chemistry 2015. We show via 3D-heteronuclear NMR spectroscopy that Aβ<inf>1-40</inf> adopts a disordered conformational ensemble with fluctuating turns in DMSO<inf>d6</inf>. Using NMR, we map the binding sites of three water-insoluble aggregation inhibitors to Aβ<inf>1-40</inf> in DMSO<inf>d6</inf> and discover remarkable differences in Aβ<inf>1-40</inf> recognition by a fourth inhibitor in H<inf>2</inf>O versus DMSO<inf>d6</inf>.
URIhttp://hdl.handle.net/10261/130613
DOI10.1039/c5ra12100k
Identifiersdoi: 10.1039/c5ra12100k
issn: 2046-2069
Appears in Collections:(IQFR) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.