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Future Trends in the Development of New Antidepressant Drugs

AutorPazos, Ángel
Fecha de publicación2014
EditorBentham Science Publishers
CitaciónCurrent Pharmaceutical Design 20(23): 3717 (2014)
ResumenMajor depression is a severe psychiatric disorder with very high prevalence and socioeconomic effect. In spite of the intensive research carried out, the biological substrate of this disease is still poorly understood. The monoaminergic theory has been for many years the moststrongly established hypotheses: in line with this, almost all antidepressant drugs currently used act by interacting with monoaminergic neurotransmission. However, these drug present serious limitations, including lack of efficacy and delayed onset of action. Recent data indicate that depression might be also associated with modifications involving cell proliferation and plasticity in some brain limbic areas. These results are leading to the identification of new pharmacological targets for the treatment of depressive disorders. This volume analyzes the most interesting recent findings in this field, suggesting new trends for the development of new and better antidepressants.
Identificadoresdoi: 10.2174/13816128113196660742
issn: 1381-6128
e-issn: 1873-4286
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