English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/130442
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

AuthorsGerlinger, Marco; Varela, Ignacio ; Swanton, Charles
Issue Date2014
PublisherNature Publishing Group
CitationNature Genetics 46(3): 225-233 (2014)
AbstractClear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and evolutionary histories of ten ccRCCs. Ultra-deep sequencing identified ITH in all cases. We found that 73-75% of identified ccRCC driver aberrations were subclonal confounding estimates of driver mutation prevalence. ITH increased with the number of biopsies analyzed, without evidence of saturation in most tumors. Chromosome 3p loss and VHL aberrations were the only ubiquitous events. The proportion of C>T transitions at CpG sites increased during tumor progression. M-seq permits the temporal resolution of ccRCC evolution and refines mutational signatures occurring during tumor development.
DescriptionPMCID: PMC4636053.-- et al.
Publisher version (URL)http://dx.doi.org/10.1038/ng.2891
URIhttp://hdl.handle.net/10261/130442
DOI10.1038/ng.2891
Identifiersdoi: 10.1038/ng.2891
e-issn: 1546-1718
issn: 1061-4036
Appears in Collections:(IBBTEC) Artículos
Files in This Item:
File Description SizeFormat 
multiregion sequencing.pdf2,4 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.