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Modulation of cyclic AMP as a new therapeutic strategy for Parkinson disease treatment

AutorMartínez, Ana ; Gil, Carmen ; Pérez Castillo, Ana ; Morales-García, José A.
Fecha de publicación2015
CitaciónAD/PD 2015
Resumen[Objectives]: Parkinson disease (PD) is the second most prevalent neurodegenerative disease and no effective treatment is available to date. In our search for new innovative drugs, we have found that PDE7 inhibitors are good drug candidates for this disease. We want now to check if the enhancement of intracellular levels of cAMP could stimulate neurogenesis events on PD animal models. [Methods]: Hemiparkinsonian rats orally treatment with S14, a small heterocyclic molecule that inhibits PDE7. Phenototypic and biochemical analysis determining neurotrophic factors modulation and neurogenesis induction. [Results]: After a S14 dose-response curve looking for phenotypic scores, we have observed a great neuroprotection of dopaminergic neurons in the substantia nigra pars compacta, accompanied by higher levels of neurotrophic factors and a consistent increase of the neurogenesis with in this brain area. [Conclusions]: Modulation of cAMP is a good therapeutic strategy to the future treatment of Parkinson disease. PDE7 inhibitors, and specifically our drug candidate S14, merit to be developed till clinical trials to assess its therapeutic potential in Parkinson disease patients.
DescripciónResumen del póster presentado a la 12th International Conference on Alzheimer's & Parkinson's Diseases, celebrada en Niza (Francia ) del 18 al 22 de marzo de 2015.
URIhttp://hdl.handle.net/10261/130252
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