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3D chromatin organization of regulatory information during development, evolution and in human diseases

AutorGómez-Skarmeta, José Luis
Fecha de publicación2014
CitaciónSymposium Reading and Interpreting the Epigenome (2014)
ResumenThe generation of distinctive cell types that form different tissues and organs requires precise, temporal and spatial control of gene expression. This depends on a vast amount of highly dynamic cis-regulatory elements distributed in the non-coding DNA. To address how this cis-regulatory information is organized in the vertebrate genome, we have employed 4C-seq to determine the regulatory landscape of multiple genes in zebra fish and mouse embryos. Our studies demonstrate that most of these genes display striking developmental and evolutionarily conserved 3D architecture that is likely essential for their correct regulation during evolution and development. Investigation of regulatory landscapes of a number of these genes in the cephalochordate amphioxus and the sea urchin genome has revealed that some of these 3D architectures have an evolutionary ancestral origin whereas others are vertebrate innovations. An enhanced understanding of 3D regulatory landscapes during development and evolution also allows us to point out unexpected genes associated with human diseases. Through our 4C-seq methodology we have recently linked alterations in 3D chromatin structure to the diabetes-associated SNPs.
DescripciónResumen del trabajo presentado al Symposium Reading and Interpreting the Epigenome: Challenges and Opportunities, celebrado en la University of Western Australia el 18 de diciembre de 2014.
URIhttp://hdl.handle.net/10261/130236
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