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Regulation of longevity by liv-7(pv17)

AutorPérez-Jiménez, Mercedes M. ; Monje, José Manuel ; Muñoz, Manuel J.
Fecha de publicación2013
Citación4th Spanish Worm Meeting (2013)
ResumenThe main objectives of this project have been the identification and characterization of a novel gene that regulates longevity in Caenorhabditis elegans. Previously, our group isolated a new long-lived mutant named liv-7 (pv17) that does not show any other visible phenotype beside the longevity phenotype. Genetic mapping of the mutation showed that liv-7 is located near to the center of chromosome V where no other long-lived mutant has been located before. Genetic interactions of liv-7 (pv17) suggest that liv-7 is involved in the control of longevity induced by germline depletion since its longevity require the transcription factors daf-16, daf-12 and pha-4, as well as kri-1, nhr-80 and tcer-1 which have been shown essential and specific for the longevity of germline depletion animals. Furthermore, liv-7 increases the intestinal nuclear localization of daf-16 a feature observed in animals without germline. In addition, the longevity of liv-7 mutant in a germline absence mutant background is not additive of the longevity observed in any of the singles. However, liv-7 mutant shows an additive increase of lifespan in different mutant backgrounds as reducing the function of the insulin/IGF pathway, sensory perception or under caloric restriction. Interestingly, the transcriptional expression of liv-7 is primarily located in four pairs of sensory neurons, ADF and ASE in the head, and PHA and PHB in the tail. All these results suggest that liv-7 could be acting in an endocrine way to regulated longevity in C. elegans, joining environmental cues and reproductive status of the animal.
DescripciónResumen del trabajo presentado al 4th Spanish Worm Meeting, celebrado en Carmona (Sevilla) del 14 al 15 de marzo de 2013.
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