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Título

In vivo analysis of neural crest behaviour in ojoplano

AutorDelfino-Machín, Mariana ; Wittbrodt, Beate; Martínez-Morales, Juan Ramón
Fecha de publicación2012
CitaciónIX Meeting of the Spanish Society for Developmental Biology (2012)
ResumenDuring embryogenesis, genetically programmed morphogenetics events occur through modifications in cellular architecture. These modifications may trigger behaviours such as the contraction of epithelial layers or cell migration events. In vertebrates, a key morphogenetic event takes place when neural crest cells delaminate from the dorsal neural tube and experiment a massive migration to finally contribute to a variety of tissues throughout the body. Our laboratory recently described the ojoplano (opo) mutant, named after its eyes phenotype, which is caused by optic cup folding defects (Martínez-Morales etal., 2009). Interetingly, opo also presents a neural crest phenotype, with many derivatives starkly reduced in number, albeit correctly differentiated. To understand what causes this phenotype, we are currently using an in vivo time-lapse imaging approach to study cell polarization and early migration in the neural crest, and specifically the role of opo during these events.
DescripciónResumen del trabajo presentado al IX Meeting of the Spanish Society for Developmental Biology celebrado en Granada del 12 al 14 de noviembre de 2012.
URIhttp://hdl.handle.net/10261/130168
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