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Cellular tiling in the cerebral cortex through contact repulsion

AuthorsBessa, José ; Luengo, Mario ; Rivero-Gil, Solangel; Ariza-Cosano, Ana ; Naranjo, Silvia ; Gómez-Skarmeta, José Luis
Issue Date2012
CitationSDB 71st Annual Meeting (2012)
AbstractCajal-Retzius (CR) cells play a fundamental role in the development of the mammalian cerebral cortex. They control the formation of cortical layers by regulating the migration of pyramidal cells through the release of Reelin. The function of CR cells critically depends on their disposition throughout the surface of the cortex, but little is known about the events controlling this phenomenon. We found that migrating CR cells repel each other upon contact, which leads to their random dispersion throughout the cortical surface and to the formation of a dynamically stable pattern of distribution that optimizes surface coverage. This process of cellular tiling is mediated by bi-directional Eph/ephrin interactions. Our observations reveal a novel mechanism that controls the even distribution of neurons in the developing brain.
DescriptionResumen del trabajo presentado al Society fro Development Biology 71st Annual Meeting, celebrado en Montreal (Canada) del 19 al 23 de julio de 2012.-- et al.
Appears in Collections:(CABD) Comunicaciones congresos
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