English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/130132
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Mitochondrial dysfunction and ROS induce inflammation in Fibromyalgia patients

AuthorsCordero, Mario D. ; Alcocer-Gómez, Elísabet; Díaz-Parrado, Eduardo; Carrión Rodríguez, Ángel Manuel ; Alfonsi, Simona; Sánchez-Alcázar, José Antonio ; Miguel, Manuel de
Issue Date2012
Citation22nd IUBMB and 37th FEBS (2012)
Abstract[Objective]: Mitochondrial dysfunction has been implicated in the pathophysiology of Fibromyalgia (FM). Inflammation has been also hypothesized in FM. We will study the possible relationship relationship between mitochondrial dysfunction, oxidative stress and inflammation in FM. [Methods]: Mitochondrial dysfunction was studied assaying Coenzyme Q10 (CoQ10), mitochondrial ROS production and mtDNA contents in blood mononuclear cells (BMCs). Serum TNF-alphaand gene expressionwas assayed as inflammatory mediator in patients. Clinical symptoms were evaluated using Visual Analogical Scale of pain (VAS), and Fibromyalgia Impact Questionnaire (FIQ). CoQ10 deficiency was induced in healthy cells and mice to evaluate TNF-alpha release. [Results]: BMCs from FM patients showed reduced level of CoQ10, mtDNA, and high level of mitochondrial ROS and TNFalpha serum and transcript levels. A significant negative correlation between CoQ10 and TNF-alpha levels (r = )0.588; p < 0.01), and a positive correlation between ROS and TNFalpha levels (r = 0.791; p < 0.001) were observed accompanied by significant correlation of VAS with TNF-alpha serum and transcript levels (r = 0.4507; p < 0.05 and r = 0.7089; p < 0.001, respectively). TNF-alpha release was observed in an in vitro and in vivo CoQ10 deficiency model. Conclusions: Our data evidence that mitochondrial dysfunction has an important role in FM. Inflammation is a mitochondrial dysfunction-depended event implicated in the pathophysiology of FM.
DescriptionResumen del póster presentado al 22nd IUBMB & 37th FEBS Congress, celebrado en Sevilla (España) del 4 al 9 de septiembre de 2012.
Appears in Collections:(CABD) Comunicaciones congresos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.