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Induction of endogenous antioxidant enzymes by endurance exercise and resveratrol treatment in the gastrocnemius muscle of old mice

AuthorsRodríguez-Bies, Elisabet ; Pozo-Cruz, Jesús del; Navas, Plácido ; López-Lluch, Guillermo
Issue Date4-Sep-2012
Citation22nd IUBMB and 37th FEBS (2012)
AbstractHuman sedentary lifestyle is the main responsible of the increasing risk for cardiovascular diseases, diabetes, obesity and other metabolic diseases. Then, it is very important to find some alternative therapies based on exercise, balanced diets and supplementation with bioactive compounds including those with antioxidant properties to ameliorate the life expectancy. We propose that moderate exercise and resveratrol can modify the expression pattern of genes involved in antioxidant protection in the muscle during aging, thereby improving cell activity and preventing the accumulation of oxidative damage. All experiments were conducted on old mice (24 month) C56BL/6 male mice. Animals were divided in four groups: ethanol control, ethanol trained, resveratrol and resveratrol trained. During six months all controls received water with vehicle (ethanol), and all R animals received water with 10 mg/100ml of trans-resveratrol (10-20 mg/kg body weight). Following four months, trained mice were exercised at 15 m/min for 20 min per day, 5 day per week for a total of 6 weeks. To determine the expression profiles of genes related to oxidative stress, RT2 Profiler PCR Array for Real-time PCR was performed. Endurance exercise and resveratrol treatment increased physical performance in old mice. Both trained and resveratrol groups also showed an increased expression of the antioxidant enzymes, such as Gpx, Txnrd, Prdx, SOD3, Nox4 involved in biological redox processes and oxidative stress response, as well as Xirp1 involved in protecting actin filaments from depolymerization. The current study shows that endurance exercise and resveratrol treatment increase physical performance in old mice and mediates improvement the antioxidant enzymes protecting skeletal muscle against oxidative stress.
DescriptionResumen del póster presentado al 22nd IUBMB & 37th FEBS Congress, celebrado en Sevilla (España) del 4 al 9 de septiembre de 2012.-- et al.
Appears in Collections:(CABD) Comunicaciones congresos
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