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Numb/Numbl-Opo antagonism controls retinal epithelium morphogenesis by regulating integrin endocytosis

AuthorsMartínez-Morales, Juan Ramón
Issue Date2012
CitationIX Meeting of the Spanish Society for Developmental Biology (2012)
AbstractPolarized trafficking of adhesion receptors plays a pivotal role in controlling cellular behavior during morphogenesis. Particulary, clathrin-dependent endocytosis of integrins has long been acknowledged as essential for cell migration. However, little is known on how oriented integrin trafficking contributes to the morphogenesis of epithelial tissues. In our laboratory we studied how the transmembrane protein Opo, previously described for its essential role during optic cup folding, plays a fundamental role in this process. Through interaction with the PTB domain of the clathrin adaptors Numb/Numbl via an integrin-like NPxF motif, Opo antagonizes Numb/Numbl function and acts as a negative regulator of integrin endocytosis. Accordingly, num/numbl gain-of-function experiments in teleost embryos mimic the retinal malformations observed in opo mutants. Taking advantage of the polarized architectute of the vertebrate retina, we studied the folding of the optic cup as a model system for epithelial basal constriction. We propose that the developmental regulators Numb/Numbl and Opo are essential components of the endocytic machinery directing the basal constriction that shapes the vertebrate retina epithelium.
DescriptionResumen del trabajo presentado al IX Meeting of the Spanish Society for Developmental Biology celebrado en Granada del 12 al 14 de noviembre de 2012.
Appears in Collections:(CABD) Comunicaciones congresos
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