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The retinal determination gene Dachshund controls the dynamics of cell shape changes during the differentiation of the Drosophila eye

AuthorsBras-Pereira, Catarina ; Casares, Fernando ; Janody, Florence
Issue Date2011
PublisherGenetics Society of America
Citation52nd Annual Drosophila Research Conference (2011)
AbstractThe Drosophila dachshund (dac) gene, the founder member of the DACH subfamily of nuclear proteins, forms part of the retinal determination pathway. Different expression and genetic studies suggest that this network is conserved in mammals. In Drosophila, previous work suggested that dac is required for the initiation of retinal differentiation. Accordingly, dac mutant flies are eyeless. However, in Dach2;Dach1 double mutant mice eyes are still present, suggesting that the functions of dac/DACH genes are not conserved. Due to this discrepancy, we have re-examined dac function during Drosophila eye development. We show that dac is not required neither for normal eye specification nor retinal differentiation, since dac mutant cells can still differentiate as photoreceptors. Furthermore, our data uncover a novel role for dac in the propagation of retinal differentiation: dac-mutant cells show abnormal cell shape dynamics that seems to cause a delay in exiting the morphogenetic furrow (MF) state, affecting MF formation and progression. Our results argue that the role of dac is not to promote the specification of the eye field, but to regulate MF dynamics.
DescriptionResumen del póster presentado al 52nd Annual Drosophila Research Conference, celebrado en San Diego, California (US) del 30 de marzo al 3 de abril de 2011.
Appears in Collections:(CABD) Comunicaciones congresos
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