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Título

Role of DaPKC in the organization of the Follicular Epithelium of the Drosophila egg chamber

AutorLearte, Anabel R. ; Sotillos, Sol ; Hernández, Rosario ; Campuzano, Sonsoles
Palabras clave52nd Annual Drosophila Research Conference
Fecha de publicación2011
EditorGenetics Society of America
Citación52nd Annual Drosophila Research Conference (2011)
ResumenDisruption of apico-basal cell polarity induces changes in cell fate, differentiation, proliferation and migration. The follicular epithelium of the Drosophila egg chamber is a very good system to address whether and how disruption of the proper function of different polarity determinants may lead to misregulation of different signalling pathways, and whether these alterations are the basis of the aberrant modifications of tissue growth and organization associated to the polarity mutants. To tackle these questions, we have focused in investigating the role of the apical determinant DaPKC, using the follicular epithelium as a model system. Our data suggest that DaPKC plays a key role in organizing epithelial structure, not only by regulation of general cell architecture features, but also through the modulation of different signalling pathways. Loss of function as well as gain of function analyses of DaPKC suggest that this kinase is required for regulation of endocytic processes in the follicular epithelium and hence, for the proper function of key signalling pathways such as Notch.
DescripciónResumen del póster presentado al 52nd Annual Drosophila Research Conference, celebrado en San Diego, California (US) del 30 de marzo al 3 de abril de 2011.
URIhttp://hdl.handle.net/10261/129994
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