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http://hdl.handle.net/10261/12973
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Boto, Alicia | en_US |
dc.contributor.author | Hernández, Dácil | en_US |
dc.contributor.author | Hernández, Rosendo | en_US |
dc.contributor.author | Álvarez, Eleuterio | en_US |
dc.date.accessioned | 2009-05-12T06:14:32Z | - |
dc.date.available | 2009-05-12T06:14:32Z | - |
dc.date.issued | 2007-11-07 | en_US |
dc.identifier.citation | Journal of Organic Chemistry 72(25): 9523-9532 (2007) | en_US |
dc.identifier.issn | 0022-3263 | - |
dc.identifier.uri | http://hdl.handle.net/10261/12973 | - |
dc.description | 10 pages, 5 tables, 6 schemes.-- PMID: 17985924 [PubMed].-- Printed version published Dec 7, 2007. | - |
dc.description | Supporting information available at: http://pubs.acs.org/doi/suppl/10.1021/jo701608p | - |
dc.description | [Synthesis and spectroscopic data of starting materials 10-13, the acyclic nucleosides 24-28, 31-37, 40-47, 49, and 50, and the alcohols 51-58; ORTEP drawings for compounds 29, 36, 37, and 45; 1H and 13C NMR spectra for compounds 24-58; and crystal structure data (in CIF format) for compounds 29, 36, 37, and 45]. | - |
dc.description.abstract | The design of processes which combine tandem and sequential reactions allows the transformation of readily available precursors into high-profit products. This strategy is illustrated by the one-pot synthesis of acyclic nucleosides, which are potential antiviral compounds, from readily available carbohydrates. The reaction conditions are mild, compatible with most functional groups. Depending on the starting sugar, both common and uncommon acyclic chains can be prepared. These polyhydroxylated chains can be combined with different bases to generate diversity. | - |
dc.description.sponsorship | This work was supported by the Investigation Programmes PPQ2000-0728 and PPQ2003-01379 of the Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica, Ministerio de Educación y Ciencia, and Ministerio de Ciencia y Tecnología, Spain. We also acknowledge financial support from FEDER funds. D.H. thanks the CSIC-Gobierno de Canarias, CSIC (I3P), and Ministerio de Educación y Ciencia (Plan Nacional FPU) for their fellowships. We thank FAES FARMA S.A. for their help in determining the cytotoxic activity of compounds 24-58. | - |
dc.format.extent | 2373 bytes | - |
dc.format.extent | 305223 bytes | - |
dc.format.mimetype | text/plain | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | American Chemical Society | - |
dc.rights | closedAccess | en_US |
dc.title | One-pot synthesis of acyclic nucleosides from carbohydrate derivatives, by combination of tandem and sequential reactions | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1021/jo701608p | - |
dc.relation.publisherversion | http://dx.doi.org/10.1021/jo701608p | - |
dc.contributor.funder | Comisión Interministerial de Ciencia y Tecnología, CICYT (España) | - |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | - |
dc.contributor.funder | Ministerio de Ciencia y Tecnología (España) | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.contributor.funder | Gobierno de Canarias | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100006280 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100007273 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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