English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/129725
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Towards the characterization of monoclonal gammopathy of undertermined significance by DSC and MALDI-TOF MS Analyses of blood serum proteome

AutorBarceló, Francisca; Portugal, José
Fecha de publicación10-jun-2015
CitaciónXVth Conress of the Spanish Biophysical Society (2015)
ResumenMonoclonal gammopathy of undetermined significance (MGUS) is a pre-malignant dyscrasia that can precede the development of multiple myeloma, a malignant neoplasia. There are no reliable biologic markers that predict which individual with MGUS will progress to MM or related condition. Therefore, improved methods and molecular biomarkers for MGUS diagnosis and its clinical evolution are needed. We are examining the suitability of DSC and MALDI-TOF MS analyses of blood sera from MGUS patients for diagnosis and clinical outcomes. DSC thermograms of serum samples distinguished healthy samples from MGUS individuals, and they showed closed connection with different peculiarities of MGUS pathology [1]. MALDI-TOF MS methodology, based on different analytical properties, is being explored to provide a complementary approach for screening MGUS disease. We have found that MGUS patients display blood serum MS profiles and peak intensities that differ from those in healthy control individuals. Our results provide novel insights into the altered protein thermogram and peptidome profile associated with MGUS. They support that DSC and MALDI-TOF techniques are promising tools for the early diagnosis and monitoring of MGUS
DescripciónPóster presentado en el XVth Congress of the Spanish Buiphysical Society, SBE, celebrado del 10 al 12 de junio de 2015, en Granada (España)
Francisco Barceló et al.
URIhttp://hdl.handle.net/10261/129725
Aparece en las colecciones: (IBMB) Comunicaciones congresos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.