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Towards the characterization of monoclonal gammopathy of undertermined significance by DSC and MALDI-TOF MS Analyses of blood serum proteome

AutorBarceló, Francisca; Portugal, José
Fecha de publicación10-jun-2015
CitaciónXVth Conress of the Spanish Biophysical Society (2015)
ResumenMonoclonal gammopathy of undetermined significance (MGUS) is a pre-malignant dyscrasia that can precede the development of multiple myeloma, a malignant neoplasia. There are no reliable biologic markers that predict which individual with MGUS will progress to MM or related condition. Therefore, improved methods and molecular biomarkers for MGUS diagnosis and its clinical evolution are needed. We are examining the suitability of DSC and MALDI-TOF MS analyses of blood sera from MGUS patients for diagnosis and clinical outcomes. DSC thermograms of serum samples distinguished healthy samples from MGUS individuals, and they showed closed connection with different peculiarities of MGUS pathology [1]. MALDI-TOF MS methodology, based on different analytical properties, is being explored to provide a complementary approach for screening MGUS disease. We have found that MGUS patients display blood serum MS profiles and peak intensities that differ from those in healthy control individuals. Our results provide novel insights into the altered protein thermogram and peptidome profile associated with MGUS. They support that DSC and MALDI-TOF techniques are promising tools for the early diagnosis and monitoring of MGUS
DescripciónPóster presentado en el XVth Congress of the Spanish Buiphysical Society, SBE, celebrado del 10 al 12 de junio de 2015, en Granada (España)
Francisco Barceló et al.
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