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Título

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors

AutorBessa, José ; Luengo, Mario ; Hanley, Neil A.; Gómez-Skarmeta, José Luis ; Vallier, Ludovic; Ferrer, Jorge
Fecha de publicación2015
EditorNature Publishing Group
CitaciónNature Cell Biology 17(5): 615-626 (2015)
ResumenThe genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages. Using human embryonic pancreas and embryonic-stem-cell-derived progenitors we identify stage-specific transcripts and associated enhancers, many of which are co-occupied by transcription factors that are essential for pancreas development. We further show that TEAD1, a Hippo signalling effector, is an integral component of the transcription factor combinatorial code of pancreatic progenitor enhancers. TEAD and its coactivator YAP activate key pancreatic signalling mediators and transcription factors, and regulate the expansion of pancreatic progenitors. This work therefore uncovers a central role for TEAD and YAP as signal-responsive regulators of multipotent pancreatic progenitors, and provides a resource for the study of embryonic development of the human pancreas.
DescripciónPMCID: PMC4434585.-- et al.
Versión del editorhttp://dx.doi.org/10.1038/ncb3160
URIhttp://hdl.handle.net/10261/129612
DOI10.1038/ncb3160
Identificadoresdoi: 10.1038/ncb3160
e-issn: 1476-4679
issn: 1465-7392
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