Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/129612COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors |
Autor: | Bessa, José CSIC ORCID; Luengo, Mario CSIC; Hanley, Neil A.; Gómez-Skarmeta, José Luis CSIC ORCID ; Vallier, Ludovic; Ferrer, Jorge | Fecha de publicación: | 2015 | Editor: | Nature Publishing Group | Citación: | Nature Cell Biology 17(5): 615-626 (2015) | Resumen: | The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for pancreatic regeneration, cancer and diabetes. We have now characterized the regulatory landscape of embryonic multipotent progenitor cells that give rise to all pancreatic epithelial lineages. Using human embryonic pancreas and embryonic-stem-cell-derived progenitors we identify stage-specific transcripts and associated enhancers, many of which are co-occupied by transcription factors that are essential for pancreas development. We further show that TEAD1, a Hippo signalling effector, is an integral component of the transcription factor combinatorial code of pancreatic progenitor enhancers. TEAD and its coactivator YAP activate key pancreatic signalling mediators and transcription factors, and regulate the expansion of pancreatic progenitors. This work therefore uncovers a central role for TEAD and YAP as signal-responsive regulators of multipotent pancreatic progenitors, and provides a resource for the study of embryonic development of the human pancreas. | Descripción: | PMCID: PMC4434585.-- et al. | Versión del editor: | http://dx.doi.org/10.1038/ncb3160 | URI: | http://hdl.handle.net/10261/129612 | DOI: | 10.1038/ncb3160 | Identificadores: | doi: 10.1038/ncb3160 e-issn: 1476-4679 issn: 1465-7392 |
| Aparece en las colecciones: | (CABD) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| TEAD YAP.pdf | 3,14 MB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
106
checked on 14-abr-2024
SCOPUSTM
Citations
157
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
155
checked on 29-feb-2024
Page view(s)
404
checked on 23-abr-2024
Download(s)
431
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.