Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/129602
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Mitochondrial responsibility in ageing process: innocent, suspect or guilty |
Autor: | López-Lluch, Guillermo CSIC ORCID CVN ; Santos-Ocaña, Carlos CSIC ORCID ; Sánchez-Alcázar, José Antonio CSIC ORCID ; Fernández-Ayala, Daniel J. M.; Asencio, Claudio CSIC; Rodríguez-Aguilera, Juan Carlos CSIC ORCID; Navas, Plácido CSIC ORCID | Palabras clave: | Organism model Caloric restriction Resveratrol Biogenesis Autophagy Ageing Mitochondria |
Fecha de publicación: | 2015 | Editor: | Springer Nature | Citación: | Biogerontology 16(5): 599-620 (2015) | Resumen: | Ageing is accompanied by the accumulation of damaged molecules in cells due to the injury produced by external and internal stressors. Among them, reactive oxygen species produced by cell metabolism, inflammation or other enzymatic processes are considered key factors. However, later research has demonstrated that a general mitochondrial dysfunction affecting electron transport chain activity, mitochondrial biogenesis and turnover, apoptosis, etc., seems to be in a central position to explain ageing. This key role is based on several effects from mitochondrial-derived ROS production to the essential maintenance of balanced metabolic activities in old organisms. Several studies have demonstrated caloric restriction, exercise or bioactive compounds mainly found in plants, are able to affect the activity and turnover of mitochondria by increasing biogenesis and mitophagy, especially in postmitotic tissues. Then, it seems that mitochondria are in the centre of metabolic procedures to be modified to lengthen life- or health-span. In this review we show the importance of mitochondria to explain the ageing process in different models or organisms (e.g. yeast, worm, fruitfly and mice). We discuss if the cause of aging is dependent on mitochondrial dysfunction of if the mitochondrial changes observed with age are a consequence of events taking place outside the mitochondrial compartment. | URI: | http://hdl.handle.net/10261/129602 | DOI: | 10.1007/s10522-015-9585-9 | Identificadores: | doi: 10.1007/s10522-015-9585-9 e-issn: 1573-6768 issn: 1389-5729 |
Aparece en las colecciones: | (CABD) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
60
checked on 22-mar-2024
WEB OF SCIENCETM
Citations
52
checked on 24-feb-2024
Page view(s)
199
checked on 28-mar-2024
Download(s)
118
checked on 28-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.