English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/129544
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Use of anodized titanium alloy as drug carrier: Ibuprofen as model of drug releasing

AuthorsDoadrio, A. L.; Conde, A. ; Arenas, M. A.; Hernández López, Juan Miguel; Damborenea, Juan de ; Pérez-Jorge, C.; Esteban, J.; Vallet-Regí, María
KeywordsReleasing
Nanotubes
Ibuprofen
Anodization
Ti6Al4V
Issue Date2015
PublisherElsevier
CitationInternational journal of pharmaceutics 492: 207-212 (2015)
Abstract© 2015 Elsevier B.V. All rights reserved. The use of osteoarticular implants has improved the quality of life of millions of patients. In this work nanotubular structures tailored made on Ti6Al4 V substrates was used as drug delivery system of ibuprofen as a proof of concept. Three different nanotubular films with different sizes and forms (NT, NT+ and NTb) were analysed. Samples were soaked in a solution of 660 mg ibuprofen/20 mL n-pentane. The ibuprofen release in aqueous medium was evaluated by liquid chromatography reversed-phase (RP-HPLC). To calculate the observed constant k, the amount of ibuprofen released was plotted versus the time using linear regression according to the zero-order, first-order, second-order and Higuchi model. The release of ibuprofen was constant and independent of the concentration. The kinetic constant obtained was 0.021 (NT), 0.022 (NT+) and 0.013 (NTb) being the correlation factor of 0.98 (zero-order) where the maximum correlation factor was reached. These results indicate that the delivery process from NT and NT+ is similar and slower that NTb. In all the cases was inside the therapeutically range. These results showed the potential of these modifications in order to develop implants that can carry different molecules of medical importance.
Publisher version (URL)http://dx.doi.org/10.1016/j.ijpharm.2015.07.046
URI10261/129544
DOI10.1016/j.ijpharm.2015.07.046
Identifiersdoi: 10.1016/j.ijpharm.2015.07.046
issn: 1873-3476
Appears in Collections:(CENIM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.