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Use of anodized titanium alloy as drug carrier: Ibuprofen as model of drug releasing

AuthorsDoadrio, A. L.; Conde, A. ; Arenas, M. A.; Hernández López, Juan Miguel; Damborenea, Juan de ; Pérez-Jorge, C.; Esteban, J.; Vallet-Regí, María
Issue Date2015
CitationInternational journal of pharmaceutics 492: 207-212 (2015)
Abstract© 2015 Elsevier B.V. All rights reserved. The use of osteoarticular implants has improved the quality of life of millions of patients. In this work nanotubular structures tailored made on Ti6Al4 V substrates was used as drug delivery system of ibuprofen as a proof of concept. Three different nanotubular films with different sizes and forms (NT, NT+ and NTb) were analysed. Samples were soaked in a solution of 660 mg ibuprofen/20 mL n-pentane. The ibuprofen release in aqueous medium was evaluated by liquid chromatography reversed-phase (RP-HPLC). To calculate the observed constant k, the amount of ibuprofen released was plotted versus the time using linear regression according to the zero-order, first-order, second-order and Higuchi model. The release of ibuprofen was constant and independent of the concentration. The kinetic constant obtained was 0.021 (NT), 0.022 (NT+) and 0.013 (NTb) being the correlation factor of 0.98 (zero-order) where the maximum correlation factor was reached. These results indicate that the delivery process from NT and NT+ is similar and slower that NTb. In all the cases was inside the therapeutically range. These results showed the potential of these modifications in order to develop implants that can carry different molecules of medical importance.
Publisher version (URL)http://dx.doi.org/10.1016/j.ijpharm.2015.07.046
Identifiersdoi: 10.1016/j.ijpharm.2015.07.046
issn: 1873-3476
Appears in Collections:(CENIM) Artículos
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