English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/129526
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Core regulatory network motif underlies the ocellar complex patterning in Drosophila melanogaster

AuthorsAguilar-Hidalgo, Daniel ; Lemos, María C.; Córdoba, Antonio
KeywordsBoolean networks
Pattern formation
Ocellar development
Robustness
Reaction–diffusion model
Issue Date2015
PublisherElsevier
CitationPhysica D: Nonlinear Phenomena 295-296: 91-102 (2015)
AbstractDuring organogenesis, developmental programs governed by Gene Regulatory Networks (GRN) define the functionality, size and shape of the different constituents of living organisms. Robustness, thus, is an essential characteristic that GRNs need to fulfill in order to maintain viability and reproducibility in a species. In the present work we analyze the robustness of the patterning for the ocellar complex formation in Drosophila melanogaster fly. We have systematically pruned the GRN that drives the development of this visual system to obtain the minimum pathway able to satisfy this pattern. We found that the mechanism underlying the patterning obeys to the dynamics of a 3-nodes network motif with a double negative feedback loop fed by a morphogenetic gradient that triggers the inhibition in a French flag problem fashion. A Boolean modeling of the GRN confirms robustness in the patterning mechanism showing the same result for different network complexity levels. Interestingly, the network provides a steady state solution in the interocellar part of the patterning and an oscillatory regime in the ocelli. This theoretical result predicts that the ocellar pattern may underlie oscillatory dynamics in its genetic regulation.
DescriptionarXiv:1404.4554v5
Publisher version (URL)http://dx.doi.org/10.1016/j.physd.2014.12.006
URIhttp://hdl.handle.net/10261/129526
DOI10.1016/j.physd.2014.12.006
Identifiersdoi: 10.1016/j.physd.2014.12.006
issn: 0167-2789
Appears in Collections:(CABD) Artículos
Files in This Item:
File Description SizeFormat 
Drosophila melanogaster pre.pdf2,91 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.