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http://hdl.handle.net/10261/129461
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Flor-Parra, Ignacio | - |
dc.contributor.author | Bernal, Manuel | - |
dc.contributor.author | Zhurinsky, Jacob | - |
dc.contributor.author | Daga, Rafael R. | - |
dc.date.accessioned | 2016-02-25T12:36:37Z | - |
dc.date.available | 2016-02-25T12:36:37Z | - |
dc.date.issued | 2014 | - |
dc.identifier | doi: 10.1242/bio.20136783 | - |
dc.identifier | e-issn: 2046-6390 | - |
dc.identifier.citation | Biology Open 3(1): 108-115 (2014) | - |
dc.identifier.uri | http://hdl.handle.net/10261/129461 | - |
dc.description | This is an Open Access article distributed under the terms of the Creative Commons Attribution License. | - |
dc.description.abstract | Yeast cells are non-motile and are encased in a cell wall that supports high internal turgor pressure. The cell wall is also essential for cellular morphogenesis and cell division. Here, we report unexpected morphogenetic changes in a Schizosaccharomyces pombe mutant defective in cell wall biogenesis. These cells form dynamic cytoplasmic protrusions caused by internal turgor pressure and also exhibit amoeboid-like cell migration resulting from repeated protrusive cycles. The cytokinetic ring responsible for cell division in wild-type yeast often fails in these cells; however, they were still able to divide using a ring-independent alternative mechanism relying on extrusion of the cell body through a hole in the cell wall. This mechanism of cell division may resemble an ancestral mode of division in the absence of cytokinetic machinery. Our findings highlight how a single gene change can lead to the emergence of different modes of cell growth, migration and division. | - |
dc.description.sponsorship | This work was supported by grants to R.R.D. from the Spanish Ministerio de Ciencia e Inovación BFU2010-21310 and P09-CTS-4697 (Proyecto de Excelencia) from La Junta de Andalucia. I.F.-P. was supported by the Spanish Ministerio de Educación (Juan de la Cierva Program). M.B. was supported by the Spanish Ministerio de Educación (FPI Fellowship, BES-2008-004018). J.Z. was supported by grant P09-CTS-4697. | - |
dc.publisher | Company of Biologists | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.subject | Turgor pressure | - |
dc.subject | Morphogenesis | - |
dc.subject | Fission yeast | - |
dc.subject | Cell migration | - |
dc.subject | Cytokinesis | - |
dc.title | Cell migration and division in amoeboid-like fission yeast | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1242/bio.20136783 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1242/bio.20136783 | - |
dc.date.updated | 2016-02-25T12:36:37Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by/3.0 | - |
dc.contributor.funder | Ministerio de Educación, Cultura y Deporte (España) | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003176 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 24357230 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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Cell migration.pdf | 765,85 kB | Adobe PDF | Visualizar/Abrir |
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