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Cell migration and division in amoeboid-like fission yeast

AuthorsFlor-Parra, Ignacio; Bernal, Manuel ; Zhurinsky, Jacob; Daga, Rafael R.
KeywordsTurgor pressure
Fission yeast
Cell migration
Issue Date2014
PublisherCompany of Biologists
CitationBiology Open 3(1): 108-115 (2014)
AbstractYeast cells are non-motile and are encased in a cell wall that supports high internal turgor pressure. The cell wall is also essential for cellular morphogenesis and cell division. Here, we report unexpected morphogenetic changes in a Schizosaccharomyces pombe mutant defective in cell wall biogenesis. These cells form dynamic cytoplasmic protrusions caused by internal turgor pressure and also exhibit amoeboid-like cell migration resulting from repeated protrusive cycles. The cytokinetic ring responsible for cell division in wild-type yeast often fails in these cells; however, they were still able to divide using a ring-independent alternative mechanism relying on extrusion of the cell body through a hole in the cell wall. This mechanism of cell division may resemble an ancestral mode of division in the absence of cytokinetic machinery. Our findings highlight how a single gene change can lead to the emergence of different modes of cell growth, migration and division.
DescriptionThis is an Open Access article distributed under the terms of the Creative Commons Attribution License.
Publisher version (URL)http://dx.doi.org/10.1242/bio.20136783
Identifiersdoi: 10.1242/bio.20136783
e-issn: 2046-6390
Appears in Collections:(CABD) Artículos
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