English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/129452
Compartir / Impacto:
Estadísticas
Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Título

Chemical tools for modulating autophagy

AutorTriola Guillem, Gemma
Palabras claveATP binding
Autophagy
Bioorganic chemistry
inhibitors
Protein kinase
Fecha de publicación21-ene-2015
EditorElsevier
CitaciónTetrahedron
ResumenAutophagy (or self-eating) is a cellular pathway that regulates the lysosomal degradation and recycling of obsolete organelles, long-lived proteins, protein aggregates and pathogens. This process occurs under basal conditions and has a crucial role in cellular development, differentiation, survival and homeostasis. In this review, an overview will be given on the autophagy modulators described up to now with the main purpose of giving the chemists interested in this research field a broad overview on the existing autophagy modulators and the methods employed for their identification. Most of the methods employed to monitor autophagy rely on the detection of the lipidated autophagy marker LC3-II (MAP1LC3, microtubule-associated proteins 1A/1B light chain 3, see below) employing antibodies recognizing both the non-lipidated LC3-I as well as LC3-II.
Versión del editorDOI: 10.1016/j.tet.2014.10.057
URIhttp://hdl.handle.net/10261/129452
DOI10.1016/j.tet.2014.10.057
Aparece en las colecciones: (IQAC) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
Triola_Tetrahedron_postprint.pdf2,8 MBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.