Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/129305
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Coenzyme Q10 therapy |
Autor: | Garrido-Maraver, Juan CSIC ORCID; Cordero, Mario D. CSIC ORCID; Oropesa-Ávila, Manuel CSIC; Fernández-Vega, Alejandro CSIC; Mata, Mario de la CSIC ORCID; Delgado Pavón, Ana CSIC; Miguel, Manuel de; Pérez-Calero, Carmen CSIC; Villanueva-Paz, Marina CSIC ORCID; Cotán, David CSIC; Sánchez-Alcázar, José Antonio CSIC ORCID | Palabras clave: | Coenzyme Q10-related compounds Clinical indications Coenzyme Q10 Pharmacokinetics |
Fecha de publicación: | 2014 | Editor: | S. Karger AG | Citación: | Molecular Syndromology 5(3-4): 187-197 (2014) | Resumen: | For a number of years, coenzyme Q10 (CoQ10) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in blood plasma, and extensively investigated its antioxidant role. These 2 functions constitute the basis for supporting the clinical use of CoQ10. Also, at the inner mitochondrial membrane level, CoQ10 is recognized as an obligatory cofactor for the function of uncoupling proteins and a modulator of the mitochondrial transition pore. Furthermore, recent data indicate that CoQ 10 affects the expression of genes involved in human cell signaling, metabolism and transport, and some of the effects of CoQ10 supplementation may be due to this property. CoQ10 deficiencies are due to autosomal recessive mutations, mitochondrial diseases, aging-related oxidative stress and carcinogenesis processes, and also statin treatment. Many neurodegenerative disorders, diabetes, cancer, and muscular and cardiovascular diseases have been associated with low CoQ10 levels as well as different ataxias and encephalomyopathies. CoQ10 treatment does not cause serious adverse effects in humans and new formulations have been developed that increase CoQ10 absorption and tissue distribution. Oral administration of CoQ10 is a frequent antioxidant strategy in many diseases that may provide a significant symptomatic benefit. | URI: | http://hdl.handle.net/10261/129305 | DOI: | 10.1159/000360101 | Identificadores: | doi: 10.1159/000360101 issn: 1661-8769 e-issn: 1661-8777 |
Aparece en las colecciones: | (CABD) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
52
checked on 17-abr-2024
SCOPUSTM
Citations
123
checked on 15-abr-2024
Page view(s)
182
checked on 23-abr-2024
Download(s)
33
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.