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dc.contributor.authorGarrido-Maraver, Juan-
dc.contributor.authorCordero, Mario D.-
dc.contributor.authorOropesa-Ávila, Manuel-
dc.contributor.authorFernández-Vega, Alejandro-
dc.contributor.authorMata, Mario de la-
dc.contributor.authorDelgado Pavón, Ana-
dc.contributor.authorMiguel, Manuel de-
dc.contributor.authorPérez Calero, Carmen-
dc.contributor.authorVillanueva Paz, Marina-
dc.contributor.authorCotán, David-
dc.contributor.authorSánchez-Alcázar, José Antonio-
dc.identifierdoi: 10.1159/000360101-
dc.identifierissn: 1661-8769-
dc.identifiere-issn: 1661-8777-
dc.identifier.citationMolecular Syndromology 5(3-4): 187-197 (2014)-
dc.description.abstractFor a number of years, coenzyme Q10 (CoQ10) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in blood plasma, and extensively investigated its antioxidant role. These 2 functions constitute the basis for supporting the clinical use of CoQ10. Also, at the inner mitochondrial membrane level, CoQ10 is recognized as an obligatory cofactor for the function of uncoupling proteins and a modulator of the mitochondrial transition pore. Furthermore, recent data indicate that CoQ 10 affects the expression of genes involved in human cell signaling, metabolism and transport, and some of the effects of CoQ10 supplementation may be due to this property. CoQ10 deficiencies are due to autosomal recessive mutations, mitochondrial diseases, aging-related oxidative stress and carcinogenesis processes, and also statin treatment. Many neurodegenerative disorders, diabetes, cancer, and muscular and cardiovascular diseases have been associated with low CoQ10 levels as well as different ataxias and encephalomyopathies. CoQ10 treatment does not cause serious adverse effects in humans and new formulations have been developed that increase CoQ10 absorption and tissue distribution. Oral administration of CoQ10 is a frequent antioxidant strategy in many diseases that may provide a significant symptomatic benefit.-
dc.description.sponsorshipThis work was supported by grants (FIS PI10/00543, FIS EC08/00076) from the Ministerio de Sanidad, Spain, and Fondo Europeo de Desarrollo Regional (FEDER-Unión Europea); Servicio Andaluz de Salud-Junta de Andalucía (SAS 111242); Proyecto de Investigación de Excelencia de la Junta de Andalucía (CTS-5725); and by AEPMI (Asociación de Enfermos de Patología Mitocondrial), FEEL (Fundación Española de Enfermedades Lisosomales) and ALBA Andalucía (Federación Andaluza de Fibromialgia y Fatiga Crónica).-
dc.publisherS. Karger AG-
dc.subjectCoenzyme Q10-related compounds-
dc.subjectClinical indications-
dc.subjectCoenzyme Q10-
dc.titleCoenzyme Q10 therapy-
dc.description.versionPeer Reviewed-
dc.contributor.funderInstituto de Salud Carlos III-
dc.contributor.funderAsociación de Enfermos de Patologías Mitocondriales (España)-
dc.contributor.funderFederación Andaluza de Fibromialgia, Síndrome de Fatiga Crónica y Sensibilidad Química Múltiple-
dc.contributor.funderEuropean Commission-
dc.contributor.funderMinisterio de Sanidad, Servicios Sociales e Igualdad (España)-
dc.contributor.funderJunta de Andalucía-
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