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http://hdl.handle.net/10261/129221
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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Maeso, Ignacio | es_ES |
dc.contributor.author | Irimia, Manuel | es_ES |
dc.contributor.author | Tena, Juan J. | es_ES |
dc.contributor.author | Casares, Fernando | es_ES |
dc.contributor.author | Gómez-Skarmeta, José Luis | es_ES |
dc.date.accessioned | 2016-02-18T12:58:47Z | - |
dc.date.available | 2016-02-18T12:58:47Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Philosophical Transactions - B - Biological Sciences 368(1632): 201300200 (2013) | es_ES |
dc.identifier.issn | 0962-8436 | - |
dc.identifier.uri | http://hdl.handle.net/10261/129221 | - |
dc.description.abstract | Despite the vast morphological variation observed across phyla, animals share multiple basic developmental processes orchestrated by a common ancestral gene toolkit. These genes interact with each other building complex gene regulatory networks (GRNs), which are encoded in the genome by cis-regulatory elements (CREs) that serve as computational units of the network. Although GRN subcircuits involved in ancient developmental processes are expected to be at least partially conserved, identification of CREs that are conserved across phyla has remained elusive. Here, we review recent studies that revealed such deeply conserved CREs do exist, discuss the difficulties associated with their identification and describe new approaches that will facilitate this search. | es_ES |
dc.description.sponsorship | J.L.G-S. and F.C acknowledge the Spanish and the Andalusian Governments and the Feder program for grants that funded this study (BFU2010-14839, BFU2009-07044, BFU2012-34324, CSD2007-00008 and Proyecto de Excelencia CVI-3488). I.M. holds a postdoctoral contract funded by the European Research Council under the European Union's Seventh Framework Programme (FP7/2007–2013)/ERC grant (268513)11. M.I. is supported by a postdoctoral fellowship from the Human Frontiers Science Program Organization. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Royal Society (Great Britain) | es_ES |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/268513 | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Cis-regulatory elements | es_ES |
dc.subject | Gene regulatory networks | es_ES |
dc.subject | Evolution | es_ES |
dc.subject | Development | es_ES |
dc.title | Deep conservation of cis-regulatory elements in metazoans | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1098/rstb.2013.0020 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1098/rstb.2013.002 | es_ES |
dc.identifier.e-issn | 1471-2970 | - |
dc.contributor.funder | Junta de Andalucía | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.contributor.funder | European Research Council | es_ES |
dc.contributor.funder | Human Frontier Science Program | es_ES |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000781 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100004412 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 24218633 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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