English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/129221
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


Deep conservation of cis-regulatory elements in metazoans

AuthorsMaeso, Ignacio; Irimia, Manuel; Tena, Juan J. ; Casares, Fernando ; Gómez-Skarmeta, José Luis
Keywordscis-regulatory element
Gene regulatory networks
Issue Date2013
PublisherRoyal Society (Great Britain)
CitationPhilosophical Transactions - B - Biological Sciences 368(1632): 201300200 (2013)
AbstractDespite the vast morphological variation observed across phyla, animals share multiple basic developmental processes orchestrated by a common ancestral gene toolkit. These genes interact with each other building complex gene regulatory networks (GRNs), which are encoded in the genome by cis-regulatory elements (CREs) that serve as computational units of the network. Although GRN subcircuits involved in ancient developmental processes are expected to be at least partially conserved, identification of CREs that are conserved across phyla has remained elusive. Here, we review recent studies that revealed such deeply conserved CREs do exist, discuss the difficulties associated with their identification and describe new approaches that will facilitate this search.
Publisher version (URL)http://dx.doi.org/10.1098/rstb.2013.002
Appears in Collections:(CABD) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.