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Title

Alterations of ultrastructural and fission/fusion markers in hepatocyte mitochondria from mice following calorie restriction with different dietary fats

AuthorsKhraiwesh, Husam; López-Domínguez, José A.; López-Lluch, Guillermo ; Navas, Plácido ; Cabo, Rafael de; Ramsey, Jon J.; Villalba, José M.; González-Reyes, José A.
KeywordsCalorie restriction
Dietary fat
Hepatocyte
Mice
Mitochondrial ultrastructure
Mitochondrial fission and fusion
Issue Date2013
PublisherOxford University Press
CitationJournals of Gerontology A - Biological Sciences and Medical Sciences 68(9): 1023-1034 (2013)
AbstractWe analyzed ultrastructural changes and markers of fission/fusion in hepatocyte mitochondria from mice submitted to 40% calorie restriction (CR) for 6 months versus ad-libitum-fed controls. To study the effects of dietary fat under CR, animals were separated into three CR groups with soybean oil (also in controls), fish oil, and lard. CR induced differential changes in hepatocyte and mitochondrial size, in the volume fraction occupied by mitochondria, and in the number of mitochondria per hepatocyte. The number of cristae per mitochondrion was significantly higher in all CR groups compared with controls. Proteins related to mitochondrial fission (Fis1 and Drp1) increased with CR, but no changes were detected in proteins involved in mitochondrial fusion (Mfn1, Mfn2, and OPA1). Although many of these changes could be attributed to CR regardless of dietary fat, changing membrane lipid composition by different fat sources did modulate the effects of CR on hepatocyte mitochondria.
Publisher version (URL)http://dx.doi.org/10.1093/gerona/glt006
URIhttp://hdl.handle.net/10261/129209
DOI10.1093/gerona/glt006
ISSN1079-5006
E-ISSN1758-535X
Appears in Collections:(CABD) Artículos
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