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| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Sánchez-Sánchez, Besaid J. | es_ES |
| dc.contributor.author | Wood, Will | es_ES |
| dc.contributor.author | Martín-Bermudo, María D. | es_ES |
| dc.date.accessioned | 2016-02-18T11:47:08Z | - |
| dc.date.available | 2016-02-18T11:47:08Z | - |
| dc.date.issued | 2013 | - |
| dc.identifier.citation | Journal of Cell Science 126(15): 3475-3484 (2013) | es_ES |
| dc.identifier.issn | 0021-9533 | - |
| dc.identifier.uri | http://hdl.handle.net/10261/129207 | - |
| dc.description | This is an Open Access article distributed under the terms of the Creative Commons Attribution License.-- et al. | es_ES |
| dc.description.abstract | Throughout embryonic development, macrophages not only act as the first line of defence against infection but also help to sculpt organs and tissues of the embryo by removing dead cells and secreting extracellular matrix components. Key to their function is the ability of embryonic macrophages to migrate and disperse throughout the embryo. Despite these important developmental functions, little is known about the molecular mechanisms underlying embryonic macrophage migration in vivo. Integrins are key regulators of many of the adult macrophage responses, but their role in embryonic macrophages remains poorly characterized. Here, we have used Drosophila macrophages (haemocytes) as a model system to address the role of integrins during embryonic macrophage dispersal in vivo. We show that the main βPS integrin, myospheroid, affects haemocyte migration in two ways; by shaping the three-dimensional environment in which haemocytes migrate and by regulating the migration of haemocytes themselves. Live imaging revealed a requirement for myospheroid within haemocytes to coordinate the microtubule and actin dynamics, and to enable haemocyte developmental dispersal, contact repulsion and inflammatory migration towards wounds. | es_ES |
| dc.description.sponsorship | This work was supported by the Spanish Ministerio de Ciencia y Tecnología [grant numbers BFU2010-16669 and CSD-2007-00008 to M.D.M.-B.] and by a Wellcome Trust Senior Research Fellowship [grant number 090899/Z/09/Z to W.W.]. R.R. was supported by the DFG as project B11 of the SFB 446 ‘Zellverhalten der Eukaryoten’]; the EMBO Young Investigator Programme [a Formación de. Personal Investigador studentship from the Spanish Ministerio de Ciencia y Tecnología [to B.J.S.-S.]. and an MRC Doctoral Training Grant to K.C. | es_ES |
| dc.language.iso | eng | es_ES |
| dc.publisher | Company of Biologists | es_ES |
| dc.relation.isversionof | Publisher's version | es_ES |
| dc.rights | openAccess | es_ES |
| dc.title | A dual role for the βPS integrin myospheroid in mediating Drosophila embryonic macrophage migration | es_ES |
| dc.type | artículo | es_ES |
| dc.identifier.doi | 10.1242/jcs.129700 | - |
| dc.description.peerreviewed | Peer reviewed | es_ES |
| dc.relation.publisherversion | http://dx.doi.org/10.1242/jcs.129700 | es_ES |
| dc.identifier.e-issn | 1477-9137 | - |
| dc.rights.license | http://creativecommons.org/licenses/by/3.0/ | es_ES |
| dc.contributor.funder | Ministerio de Ciencia y Tecnología (España) | es_ES |
| dc.contributor.funder | Wellcome Trust | es_ES |
| dc.contributor.funder | EMBO | es_ES |
| dc.relation.csic | Sí | es_ES |
| dc.identifier.funder | http://dx.doi.org/10.13039/501100006280 | es_ES |
| dc.identifier.funder | http://dx.doi.org/10.13039/100004440 | es_ES |
| dc.identifier.funder | http://dx.doi.org/10.13039/501100003043 | es_ES |
| dc.identifier.pmid | 23704353 | - |
| dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| item.fulltext | With Fulltext | - |
| item.cerifentitytype | Publications | - |
| item.openairetype | artículo | - |
| item.languageiso639-1 | en | - |
| item.grantfulltext | open | - |
| Aparece en las colecciones: | (CABD) Artículos | |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| macrophage migration.pdf | 4,26 MB | Adobe PDF |  Visualizar/Abrir |
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