Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/129079
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Irimia, Manuel | - |
dc.contributor.author | Royo, José Luis | - |
dc.contributor.author | Burguera, Demian | - |
dc.contributor.author | Maeso, Ignacio | - |
dc.contributor.author | Gómez-Skarmeta, José Luis | - |
dc.contributor.author | Garcia-Fernàndez, Jordi | - |
dc.date.accessioned | 2016-02-15T10:36:57Z | - |
dc.date.available | 2016-02-15T10:36:57Z | - |
dc.date.issued | 2012 | - |
dc.identifier | doi: 10.1038/srep00433 | - |
dc.identifier | issn: 2045-2322 | - |
dc.identifier.citation | Scientific Reports 2: 433 (2012) | - |
dc.identifier.uri | http://hdl.handle.net/10261/129079 | - |
dc.description | This work is licensed under a Creative Commons Attribution-NonCommercial-ShareALike 3.0 Unported License. | - |
dc.description.abstract | The origin and evolution of the complex regulatory landscapes of some vertebrate developmental genes, often spanning hundreds of Kbp and including neighboring genes, remain poorly understood. The Sonic Hedgehog (Shh) genomic regulatory block (GRB) is one of the best functionally characterized examples, with several discrete enhancers reported within its introns, vast upstream gene-free region and neighboring genes (Lmbr1 and Rnf32). To investigate the origin and evolution of this GRB, we sequenced and characterized the Hedgehog (Hh) loci from three invertebrate chordate amphioxus species, which share several early expression domains with Shh. Using phylogenetic footprinting within and between chordate lineages, and reporter assays in zebrafish probing >30 Kbp of amphioxus Hh, we report large sequence and functional divergence between both groups. In addition, we show that the linkage of Shh to Lmbr1 and Rnf32, necessary for the unique gnatostomate-specific Shh limb expression, is a vertebrate novelty occurred between the two whole-genome duplications. | - |
dc.description.sponsorship | M.I., D.B., I.M. and J.G.-F. were funded by Grants BFU2005-00252 and BMC2008-03776 and BMC2011-23291 from the Spanish Ministry of Science and Innovation, and J.G.F. by the ICREA Academia Prize. M.I., D.B. and I.M. held FPI, APIF-UB and FPU fellowships, respectively. J.-L.G.-S. and J.L.R. were supported by Grants BFU2010-14839, CSD2007-00008875 (MEC), and CVI 3488 (Junta de Andalucía). JLR holds a JAE-Doc grant from the National Research Council, founded by Social European Funds. | - |
dc.publisher | Nature Publishing Group | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Comparative genomics of the Hedgehog loci in chordates and the origins of Shh regulatory novelties | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1038/srep00433 | - |
dc.relation.publisherversion | http://dx.doi.org/10.1038/srep00433 | - |
dc.date.updated | 2016-02-15T10:36:59Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by-nc-sa/3.0/ | - |
dc.contributor.funder | Consejo Superior de Investigaciones Científicas (España) | - |
dc.contributor.funder | European Commission | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | - |
dc.contributor.funder | Institución Catalana de Investigación y Estudios Avanzados | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.relation.csic | Sí | - |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003339 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003741 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 22666536 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
Aparece en las colecciones: | (CABD) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Hedgehogloci.pdf | 573,55 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
11
checked on 06-mar-2024
SCOPUSTM
Citations
26
checked on 15-mar-2024
WEB OF SCIENCETM
Citations
25
checked on 29-feb-2024
Page view(s)
291
checked on 18-mar-2024
Download(s)
198
checked on 18-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.