English   español  
Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/129074
COMPARTIR / IMPACTO:
Estadísticas
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Título

Oral coenzyme Q10 supplementation improves clinical symptoms and recovers pathologic alterations in blood mononuclear cells in a fibromyalgia patient

AutorCordero, Mario D. ; Cotán, David ; Pozo-Martín, Yaiza del; Carrión Rodríguez, Ángel Manuel ; Miguel, Manuel de; Bullón, Pedro; Sánchez-Alcázar, José Antonio
Palabras claveMitochondrial biogenesis
Oxidative stress
Coenzyme Q
Fibromyalgia
Fecha de publicación2012
EditorElsevier
CitaciónNutrition 28(11-12): 1200-1203 (2012)
ResumenFibromyalgia (FM) is a chronic pain syndrome with unknown etiology. Recent studies have shown evidence demonstrating that mitochondrial dysfunction and oxidative stress may have a role in the pathophysiology of FM. Coenzyme Q10 (CoQ10) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Low CoQ10 levels have been detected in patients with FM, and a significant decrease of clinical symptoms has been reported after oral CoQ10 supplementation. In this report, we show the effect of CoQ10 treatment on clinical symptoms, blood mononuclear cells, and mitochondrial and oxidative stress markers from a woman with FM. After CoQ10 treatment, the patient reported a significant improvement of clinical symptoms. At the cellular level, CoQ10 treatment restored mitochondrial dysfunction and the mtDNA copy number, decreased oxidative stress, and increased mitochondrial biogenesis. Our results suggest that CoQ10 could be an alternative therapeutic approach for FM. © 2012.
URIhttp://hdl.handle.net/10261/129074
DOI10.1016/j.nut.2012.03.018
Identificadoresdoi: 10.1016/j.nut.2012.03.018
issn: 0899-9007
e-issn: 1873-1244
Aparece en las colecciones: (CABD) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato  
accesoRestringido.pdf15,38 kBAdobe PDFVista previa
Visualizar/Abrir
Mostrar el registro completo
 

Artículos relacionados:


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.