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dc.contributor.authorFreitas, Renata-
dc.contributor.authorGómez-Marín, Carlos-
dc.contributor.authorWilson, Jonathan Mark-
dc.contributor.authorCasares, Fernando-
dc.contributor.authorGómez-Skarmeta, José Luis-
dc.date.accessioned2016-02-12T11:40:09Z-
dc.date.available2016-02-12T11:40:09Z-
dc.date.issued2012-
dc.identifierdoi: 10.1016/j.devcel.2012.10.015-
dc.identifierissn: 1534-5807-
dc.identifiere-issn: 1878-1551-
dc.identifier.citationDevelopmental Cell 23(6): 1219- 1229 (2012)-
dc.identifier.urihttp://hdl.handle.net/10261/129048-
dc.description.abstractFossil data suggest that limbs evolved from fish fins by sequential elaboration of their distal endoskeleton, giving rise to the autopod close to the tetrapod origin. This elaboration may have occurred by a simultaneous reduction of the distal ectodermal fold of fish fins. Modulation of 5' Hoxd gene transcription, through tetrapod-specific digit enhancers, has been suggested as a possible evolutionary mechanism involved in these morphological transformations. Here, we overexpress hoxd13a in zebrafish to investigate the impact of increasing 5' Hoxd expression during fin development. This overexpression causes increased proliferation, distal expansion of chondrogenic tissue and finfold reduction. In addition, we also show that the tetrapod-specific 5' Hoxd enhancer CsC promotes similar expression in zebrafish fins and mouse limbs. Our results support the idea that modulation of 5' Hoxd gene expression, by acquisition of novel enhancer elements, offered the substrate for the evolution of fins and the origin of tetrapod limbs. Freitas et al provide functional evidence supporting the hypothesis that modulation of 5' Hoxd transcription, through the addition of novel enhancer elements, was a key evolutionary mechanism for the distal elaboration of vertebrate appendages. This elaboration evolved into the distal limbs of tetrapods and allowed the colonization of land by vertebrates.-
dc.description.sponsorshipThis work was funded by the Spanish and the Andalusian Governments (grants BFU2010-14839, BFU2009-07044, CSD2007-00008, Proyecto de Excelencia CVI-3488, and CVI-2658) and supported by FEDER. R.F. was funded by an EMBO Long-Term Fellowship, a Marie Curie Intra-European fellowship, and Fundação para a Ciência e a Tecnologia (FCT; SFRH/BPD/73252/2010, Portugal).-
dc.publisherElsevier-
dc.rightsclosedAccess-
dc.titleHoxd13 contribution to the evolution of vertebrate Aappendages-
dc.typeartículo-
dc.identifier.doi10.1016/j.devcel.2012.10.015-
dc.date.updated2016-02-12T11:40:11Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderEuropean Commission-
dc.contributor.funderEMBO-
dc.contributor.funderFundação para a Ciência e a Tecnologia (Portugal)-
dc.contributor.funderJunta de Andalucía-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003043es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001871es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100011011es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
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