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Benzaldehyde Lyase-catalyzed intramolecular benzoin reactions

AuthorsHernández Sánchez, Karel ; Petrillo, Giovanna ; Usón, Isabel ; Wandtke, Claudia M.; Joglar Tamargo, Jesús ; Parella, Teodor; Clapés Saborit, Pere ; Bujons Vilàs, Jordi
Issue Date26-Jul-2015
CitationBIOTRANS 2015
AbstractIntramolecular stereoselective carboligations are important reactions in organic synthetic chemistry essential for the access of natural occurring compounds and analogues. Besides the chemical methodologies, a plethora of intramolecular C-C bond forming reactions exists in different metabolic pathways of living organism catalyzed by highly evolved enzymes. Examples of carboligases such as of aldolases or ThDP depending enzymes performing asymmetric intramolecular aldol reactions with synthetic substrates are scarce in the literature. In this work, we endeavored to investigate on the intramolecular C-C bond formation via benzoin reaction catalyzed by benzaldehyde lyase from Pseudomonas fluorescens biovar I (BAL). We investigate BAL-catalyzed intramolecular benzoin reaction on benzaldehyde moieties substrates connected with a spacer derivative via ether linkage (i.e. 2,2'- (1), 3,3’ (2) and 4,4’ (3)-(n-alkane-1,n-diylbis(oxy))dibenzaldehyde derivatives). The reaction performance comparing the intra and inter benzoin reaction with substrates 1-3 as well as their analogues with symmetric and unsymmetrical aromatic substitutions was investigated. The results obtained of substrate conversion, stereochemical outcome of the enzymatic reactions and molecular models that intended to explain the reactivity of the different substrates will be reported.
DescriptionPóster presentado en BIOTRANS 2015, celebrado del 26 al 30 de julio de 2015 en Viena (Austria)
Appears in Collections:(IQAC) Comunicaciones congresos
(IBMB) Comunicaciones congresos
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