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Título

Mitochondrial dysfunction promoted by Porphyromonas gingivalis lipopolysaccharide as a possible link between cardiovascular disease and periodontitis

AutorBullón, Pedro; Cordero, Mario D. ; Quiles, José Luis; Morillo, Juan Manuel; Ramírez-Tortosa, María del Carmen; Battino, Maurizio
Palabras claveApoptosis
Mitochondrial membrane potential
Reactive oxygen species
Cardiovascular disease
Free radicals
Periodontitis
CoQ10
Fecha de publicación2011
EditorElsevier
CitaciónFree Radical Biology and Medicine 50(10): 1336-1343 (2011)
ResumenOxidative stress is one of the factors that could explain the pathophysiological mechanism of inflammatory conditions that occur in cardiovascular disease (CVD) and periodontitis. Such inflammatory response is often evoked by specific bacteria, as the lipopolysaccharide (LPS) of Porphyromonas gingivalis is a key factor in this process. The aim of this research was to study the role of mitochondrial dysfunction in peripheral blood mononuclear cells (PBMCs) from periodontitis patients and to evaluate the influence of LPS on fibroblasts to better understand the pathophysiology of periodontitis and its relationship with CVD. PBMCs from patients showed lower CoQ10 levels and citrate synthase activity, together with high levels of ROS production. LPS-treated fibroblasts provoked increased oxidative stress and mitochondrial dysfunction by a decrease in mitochondrial protein expression, mitochondrial mass, and mitochondrial membrane potential. Our study supports the hypothesis that LPS-mediated mitochondrial dysfunction could be at the origin of oxidative stress in periodontal patients. Abnormal PBMC performance may promote oxidative stress and alter cytokine homeostasis. In conclusion, mitochondrial dysfunction could represent a possible link to understanding the interrelationships between two prominent inflammatory diseases: periodontitis and CVD.
URIhttp://hdl.handle.net/10261/128996
DOI10.1016/j.freeradbiomed.2011.02.018
Identificadoresdoi: 10.1016/j.freeradbiomed.2011.02.018
issn: 0891-5849
e-issn: 1873-4596
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