English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/128988
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Vaccinia-related kinase 1 is required for early uterine development in Caenorhabditis elegans

AuthorsDobrzynska, Agnieszka ; Askjaer, Peter
KeywordsAnchor cell
Cell fusion
MosSCI
Protein kinase
Uterine development
VRK1
Issue Date2016
PublisherElsevier
CitationDevelopmental Biology 411(2): 246-256 (2016)
AbstractProtein kinases regulate a multitude of processes by reversible phosphorylation of target molecules. Induction of cell proliferation and differentiation are fundamental to development and rely on tightly controlled kinase activities. Vaccinia-Related Kinases (VRKs) have emerged as a multifunctional family of kinases with essential functions conserved, from nematodes and fruit flies, to humans. VRK substrates include chromatin and transcription factors, whereas deregulation of VRKs is implicated in sterility, cancer and neurological defects. In contrast to previous observations, we describe here that Caenorhabditis elegans VRK-1 is expressed in all cell types, including proliferating and post-mitotic cells. Despite the ubiquitous expression pattern, we find that vrk-1 mutants are particularly impaired in uterine development. Our data show that VRK-1 is required for uterine cell proliferation and differentiation. Moreover, the anchor cell, a specialized uterine cell, fails to fuse with neighboring cells to form the utse syncytium in vrk-1 mutants, thus providing further insight on the role of VRKs in organogenesis.
Publisher version (URL)http://dx.doi.org/10.1016/j.ydbio.2016.01.010
URIhttp://hdl.handle.net/10261/128988
DOI10.1016/j.ydbio.2016.01.010
ISSN0012-1606
Appears in Collections:(CABD) Artículos
Files in This Item:
File Description SizeFormat 
Caenorhabditis elegans.pdf6,21 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.