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Título

The guanine exchange factor vav controls axon growth and guidance during Drosophila development

AutorMalartre, Marianne; Ayaz, Derya; Fernández Amador, Fátima; Martín-Bermudo, María D.
Fecha de publicación2010
EditorSociety for Neuroscience
CitaciónJournal of Neuroscience 30(6): 2257-2267 (2010)
ResumenThe Vav proteins are guanine exchange factors (GEFs) that trigger the activation of the Rho GTPases in general and the Rac family in particular. While the role of the mammalian vav genes has been extensively studied in the hematopoietic system and the immune response, there is little information regarding the role of vav outside of these systems. Here, we report that the single Drosophila vav homolog is ubiquitously expressed during development, although it is enriched along the embryonic ventral midline and in the larval eye discs and brain. We have analyzed the role that vav plays during development by generating Drosophila null mutant alleles. Our results indicate that vav is required during embryogenesis to prevent longitudinal axons from crossing the midline. Later on, during larval development, vav is required within the axons to regulate photoreceptor axon targeting to the optic lobe. Finally, we demonstrate that adult vav mutant escapers, which exhibit coordination problems, display axon growth defects in the ellipsoid body, a brain area associated with locomotion control. In addition, we show that vav interacts with other GEFs known to act downstream of guidance receptors. Thus, we propose that vav acts in coordination with other GEFs to regulate axon growth and guidance during development by linking guidance signals to the cytoskeleton via the modulation of Rac activity.
Versión del editorhttp://dx.doi.org/10.1523/JNEUROSCI.1820-09.2010
URIhttp://hdl.handle.net/10261/128936
DOI10.1523/JNEUROSCI.1820-09.2010
Identificadoresdoi: 10.1523/JNEUROSCI.1820-09.2010
issn: 0270-6474
e-issn: 1529-2401
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